Autoimmunity: Are We Asking the Right Question?

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Nov 21

PMID 36405714

Authors

Polly Matzinger

Affiliations

Soon will be listed here.

Abstract

For decades, the main question immunologists have asked about autoimmunity is "what causes a break in self-tolerance?" We have not found good answers to that question, and I believe we are still so ignorant because it's the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.

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