The Role of NLRP3 Inflammasome in Inflammation-related Skeletal Muscle Atrophy

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Nov 21

PMID 36405697

Authors

Yukun Liu

Dongfang Wang

Tianyu Li

Fan Yang

Zhanfei Li

Xiangjun Bai

Yuchang Wang

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival. Although several advances have been made in investigations on the pathogenetic mechanism of sepsis-induced skeletal muscle atrophy, the underlying mechanisms remain unclear. Findings from recent studies suggest that the nucleotide-binding and oligomerisation domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a regulator of inflammation, may be crucial in the development of skeletal muscle atrophy. NLRP3 inhibitors contribute to the inhibition of catabolic processes, skeletal muscle atrophy and cachexia-induced inflammation. Here, we review the mechanisms by which NLRP3 mediates these responses and analyse how NLRP3 affects muscle wasting during inflammation.

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