QUS Characteristics in Normal Population: a Mini Review and Our Experience

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2022 Nov 21

PMID 36404808

Authors

Maryam Najafi

Minoo Najafi

Abbas Ali Keshtkar

Mojtaba Sedaghat

Ali Reza Khalilifard

Bagher Larijani

Zohreh Hamidi

Affiliations

Soon will be listed here.

Abstract

Objectives: Quantitative ultrasound (QUS) is a bone densitometry method that is less expensive and more portable than DXA. It is also noninvasive. QUS parameters include speed of sound (SOS), broad band ultrasound attenuation (BUA), and stiffness index (SI). This study defined normal values of QUS parameters in Iranian men and women.

Methods: QUS of heels measured in 258 Iranian men and women, aged 20-76 y/o. They were participants of Iranian Multicenter Osteoporosis study (IMOS), selected by randomized sampling. QUS device was an Achilles+ (GE-Lunar) device.

Results: Percentiles of SI (2.5%, 50%, and 97.5%) determined. We found a good agreement between the Iranian reference values and western reference (used by device) value in defining normal and osteoporotic people (κ = 0.875).

Conclusion: Results from this study suggest that QUS of the heel may be a good method for diagnosis of low bone mass in different regions.

References

Sandstrom L, McGuigan F, Callreus M, Akesson K . Peak Bone Mass and Quantitative Ultrasound Bone Properties in Young Adulthood: A Study in the PEAK-25 Cohort of Women. J Clin Densitom. 2016; 19(4):477-484. DOI: 10.1016/j.jocd.2016.03.001. View

Hamidi Z, Sedaghat M, Hejri S, Larijani B . Defining cut-off values for the diagnosis of osteoporosis in postmenopausal women by quantitative ultrasonography of the phalanx. Gynecol Endocrinol. 2008; 24(10):546-8. DOI: 10.1080/09513590802340548. View

Black D, Cummings S, Genant H, Nevitt M, Palermo L, Browner W . Axial and appendicular bone density predict fractures in older women. J Bone Miner Res. 1992; 7(6):633-8. DOI: 10.1002/jbmr.5650070607. View

Beerhorst K, Tan J, Tan I, Verschuure P, Aldenkamp A . Dual-energy X-ray absorptiometry versus quantitative ultrasonography in diagnosing osteoporosis in patients with refractory epilepsy and chronic antiepileptic drug use. Ther Adv Musculoskelet Dis. 2013; 5(2):59-66. PMC: 3638315. DOI: 10.1177/1759720X13475851. View

Frost M, Blake G, Fogelman I . Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?. Osteoporos Int. 2000; 11(4):321-30. DOI: 10.1007/s001980070121. View

Yeap S, Pearson D, Cawte S, Hosking D . The relationship between bone mineral density and ultrasound in postmenopausal and osteoporotic women. Osteoporos Int. 1998; 8(2):141-6. DOI: 10.1007/BF02672510. View

Wasnich R, Ross P, Heilbrun L, Vogel J . Selection of the optimal skeletal site for fracture risk prediction. Clin Orthop Relat Res. 1987; (216):262-9. View

Bossy E, Talmant M, Peyrin F, Akrout L, Cloetens P, Laugier P . An in vitro study of the ultrasonic axial transmission technique at the radius: 1-MHz velocity measurements are sensitive to both mineralization and intracortical porosity. J Bone Miner Res. 2004; 19(9):1548-56. DOI: 10.1359/JBMR.040513. View

Hashmi F, Elfandi K . Heel Ultrasound Scan in Detecting Osteoporosis in Low Trauma Fracture Patients. Orthop Rev (Pavia). 2016; 8(2):6357. PMC: 4933818. DOI: 10.4081/or.2016.6357. View

10.

Chin K, Low N, Kamaruddin A, Dewiputri W, Soelaiman I . Agreement between calcaneal quantitative ultrasound and osteoporosis self-assessment tool for Asians in identifying individuals at risk of osteoporosis. Ther Clin Risk Manag. 2017; 13:1333-1341. PMC: 5640400. DOI: 10.2147/TCRM.S145519. View

11.

Grampp S, Henk C, Lu Y, Krestan C, Resch H, Kainberger F . Quantitative US of the calcaneus: cutoff levels for the distinction of healthy and osteoporotic individuals. Radiology. 2001; 220(2):400-5. DOI: 10.1148/radiology.220.2.r01au05400. View

12.

Frediani B, Acciai C, Falsetti P, Baldi F, Filippou G, Siagkri C . Calcaneus ultrasonometry and dual-energy X-ray absorptiometry for the evaluation of vertebral fracture risk. Calcif Tissue Int. 2006; 79(4):223-9. DOI: 10.1007/s00223-005-0098-4. View

13.

Trimpou P, Bosaeus I, Bengtsson B, Landin-Wilhelmsen K . High correlation between quantitative ultrasound and DXA during 7 years of follow-up. Eur J Radiol. 2009; 73(2):360-4. DOI: 10.1016/j.ejrad.2008.11.024. View

14.

Raum K, Leguerney I, Chandelier F, Bossy E, Talmant M, Saied A . Bone microstructure and elastic tissue properties are reflected in QUS axial transmission measurements. Ultrasound Med Biol. 2005; 31(9):1225-35. DOI: 10.1016/j.ultrasmedbio.2005.05.002. View

15.

Svedbom A, Hernlund E, Ivergard M, Compston J, Cooper C, Stenmark J . Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos. 2013; 8:137. PMC: 3880492. DOI: 10.1007/s11657-013-0137-0. View

16.

Hammad L . Measurements of bone mineral density and stiffness index in young Saudi females. Pak J Med Sci. 2016; 32(2):399-402. PMC: 4859031. DOI: 10.12669/pjms.322.9757. View

17.

Choksi P, Jepsen K, Clines G . The challenges of diagnosing osteoporosis and the limitations of currently available tools. Clin Diabetes Endocrinol. 2018; 4:12. PMC: 5975657. DOI: 10.1186/s40842-018-0062-7. View

18.

Thomsen K, Jepsen D, Matzen L, Hermann A, Masud T, Ryg J . Is calcaneal quantitative ultrasound useful as a prescreen stratification tool for osteoporosis?. Osteoporos Int. 2015; 26(5):1459-75. DOI: 10.1007/s00198-014-3012-y. View

19.

Pluskiewicz W, Drozdzowska B . Ultrasonic measurement of the calcaneus in Polish normal and osteoporotic women and men. Bone. 1999; 24(6):611-7. DOI: 10.1016/s8756-3282(99)00089-7. View

20.

Larijani B, Dabbaghmanesh M, Aghakhani S, Sedaghat M, Hamidi Z, Rahimi E . Correlation of quantitative heel ultrasonography with central dual-energy X-ray absorptiometric bone mineral density in postmenopausal women. J Ultrasound Med. 2005; 24(7):941-6. DOI: 10.7863/jum.2005.24.7.941. View