» Articles » PMID: 36404025

The Role of Vascular Risk Factors in Cognitive Impairment and Dementia and Prospects for Prevention

Overview
Specialty Geriatrics
Date 2022 Nov 20
PMID 36404025
Authors
Affiliations
Soon will be listed here.
Abstract

One of the most challenging clinical expressions of population aging is cognitive impairment and dementia. Among risk factors for the development of dementia, modifiable vascular risk factors have emerged as contributors to both vascular and nonvascular types of dementia. Epidemiologic studies have been particularly informative in understanding the link between vascular risks and dementia across the life course. We discuss vascular risks for dementia and cognitive impairment and practical management recommendations.

Citing Articles

Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain.

Gulej R, Nyul-Toth A, Csik B, Patai R, Petersen B, Negri S Geroscience. 2024; 46(5):4415-4442.

PMID: 38727872 PMC: 11336025. DOI: 10.1007/s11357-024-01154-8.


The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.

Kalaria R, Maestre G, Mahinrad S, Acosta D, Akinyemi R, Alladi S Alzheimers Dement. 2024; 20(6):4290-4314.

PMID: 38696263 PMC: 11180946. DOI: 10.1002/alz.13836.


What will it take to achieve brain health globally?.

Gorelick P, Hainsworth A, Wallin A Cereb Circ Cogn Behav. 2024; 6:100209.

PMID: 38328025 PMC: 10847852. DOI: 10.1016/j.cccb.2024.100209.


What have clinical trials taught us about brain health?.

Lee K, Bae H Cereb Circ Cogn Behav. 2024; 6:100199.

PMID: 38235315 PMC: 10792690. DOI: 10.1016/j.cccb.2023.100199.

References
1.
Lane C, Barnes J, Nicholas J, Sudre C, Cash D, Malone I . Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort. JAMA Neurol. 2019; 77(2):175-183. PMC: 6830432. DOI: 10.1001/jamaneurol.2019.3774. View

2.
Peters R, Yasar S, Anderson C, Andrews S, Antikainen R, Arima H . Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis. Neurology. 2019; 94(3):e267-e281. PMC: 7108807. DOI: 10.1212/WNL.0000000000008732. View

3.
Unger T, Borghi C, Charchar F, Khan N, Poulter N, Prabhakaran D . 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020; 75(6):1334-1357. DOI: 10.1161/HYPERTENSIONAHA.120.15026. View

4.
Cataldo J, Prochaska J, Glantz S . Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation. J Alzheimers Dis. 2010; 19(2):465-80. PMC: 2906761. DOI: 10.3233/JAD-2010-1240. View

5.
Erickson K, Donofry S, Sewell K, Brown B, Stillman C . Cognitive Aging and the Promise of Physical Activity. Annu Rev Clin Psychol. 2022; 18:417-442. DOI: 10.1146/annurev-clinpsy-072720-014213. View