The Biofire® Filmarray® Pneumonia Plus Panel for Management of Lower Respiratory Tract Infection in Mechanically-ventilated Patients in the COVID-19 Era: a Diagnostic and Cost-benefit Evaluation

Overview

Journal Diagn Microbiol Infect Dis

Specialties Infectious Diseases
Microbiology
Pathology

Date 2022 Nov 20

PMID 36403558

Authors

Josep Ferrer

Maria Angeles Clari

Estela Gimenez

Nieves Carbonell

Ignacio Torres

Maria Luisa Blasco

Eliseo Albert

David Navarro

Affiliations

Soon will be listed here.

Abstract

We assessed the diagnostic performance of the Biofire® Filmarray® Pneumonia Plus panel (FA-PP) compared to standard culture in Intensive Care Unit patients with suspected ventilator-associated lower respiratory tract infection in the COVID-19 era. We determined whether its implementation in routine diagnostic algorithms would be cost-beneficial from a hospital perspective. Of 163 specimens, 96 (59%) returned negative results with FA-PP and conventional culture, and 29 specimens (17.8%) were positive with both diagnostic methods and yielded concordant qualitative bacterial identification/isolation. Thirty-nine specimens (23.9%) gave discordant results (positive via FA-PP and negative via culture). Real-life adjustments of empirical antimicrobial therapy (EAT) after FA-PP results resulted in additional costs beyond EAT alone of 1868.7 €. Adequate EAT adjustments upon FA-PP results would have resulted in a saving of 6675.8 €. In conclusion, the data presented supports the potential utility of FA-PP for early EAT adjustment in patients with ventilator-associated lower respiratory tract infection.

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