Higher Dietary Acid Load is Associated with Hyperuricemia in Chinese Adults: a Case-control Study

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2022 Nov 19

PMID 36401201

Authors

Si-Si Shao

Chong-Ze Lin

Yong-Fu Zhu

Chun Chen

Qian-Jia Wu

Ruo-Ru Chen

Affiliations

Soon will be listed here.

Abstract

Background: This study aims to explore the association between dietary acid load and hyperuricemia in Chinese adults.

Methods: A case-control study was conducted. Adult participants with hyperuricemia were recruited as the cases and those without hyperuricemia were as the controls. Food consumption was evaluated by food frequency questionnaire (FFQ). Dietary acid load was assessed by potential renal acid load (PRAL) and net endogenous acid production (NEAP). Dietary acid load was divided into four levels: the first quartile (Q1), the second quartile (Q2), the third quartile (Q3) and the fourth quartile (Q4). Logistic regression model was applied for exploring the association between dietary acid load (PRAL and NEAP) and hyperuricemia. Odds ratio (OR) and its correspondence confidence interval (CI) were computed.

Results: A total of 290 participants were eligible in this study, in which there were 143 individuals in case group and 147 in control group. A higher level of PRAL was found to be associated with odds of hyperuricemia. ORs of hyperuricemia for Q2, Q3 and Q4 of PRAL were 2.74 (95%CI: 1.94 ~ 3.88, p-value: 0.004), 2.90 (95%CI: 2.05 ~ 4.10, p-value: 0.002) and 3.14 (95%CI: 2.22 ~ 4.45, p-value: 0.001), respectively. There was a positive association between elevated NEAP and hyperuricemia. OR of hyperuricemia for Q2 was not material significance (OR:1.54, 95%CI: 0.93 ~ 2.53, p-value: 0.210), however, ORs of hyperuricemia for Q3 (OR: 2.40, 95%CI: 1.70 ~ 3.38, p-value: 0.011) and Q4 (OR: 3.27, 95%CI: 2.31 ~ 4.62, p-value: 0.001) were statistically significant.

Conclusion: Higher level of dietary acid load was found to be associated with hyperuricemia in Chinese adults, indicative of advocation of a well-balanced diet in this population.

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References

Li M, Shi Z . Ultra-Processed Food Consumption Associated with Overweight/Obesity among Chinese Adults-Results from China Health and Nutrition Survey 1997-2011. Nutrients. 2021; 13(8). PMC: 8399660. DOI: 10.3390/nu13082796. View

Chen-Xu M, Yokose C, Rai S, Pillinger M, Choi H . Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016. Arthritis Rheumatol. 2019; 71(6):991-999. PMC: 6536335. DOI: 10.1002/art.40807. View

Farhangi M, Vajdi M, Najafi M . Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery. PLoS One. 2019; 14(10):e0223830. PMC: 6797202. DOI: 10.1371/journal.pone.0223830. View

Aihemaitijiang S, Zhang Y, Zhang L, Yang J, Ye C, Halimulati M . The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents. Nutrients. 2020; 12(12). PMC: 7765492. DOI: 10.3390/nu12123835. View

Mozaffari H, Siassi F, Guilani B, Askari M, Azadbakht L . Association of dietary acid-base load and psychological disorders among Iranian women: A cross-sectional study. Complement Ther Med. 2020; 53:102503. DOI: 10.1016/j.ctim.2020.102503. View

Mirmiran P, Houshialsadat Z, Bahadoran Z, Khalili-Moghadam S, Shahrzad M, Azizi F . Dietary acid load and risk of cardiovascular disease: a prospective population-based study. BMC Cardiovasc Disord. 2021; 21(1):432. PMC: 8436514. DOI: 10.1186/s12872-021-02243-8. View

Mortada I . Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association. Curr Hypertens Rep. 2017; 19(9):69. DOI: 10.1007/s11906-017-0770-x. View

Lai X, Gao B, Zhou G, Zhu Q, Zhu Y, Lai H . The Association between Baseline, Changes in Uric Acid, and Renal Failure in the Elderly Chinese Individuals: A Prospective Study with a 3-Year Follow-Up. Int J Endocrinol. 2022; 2022:4136373. PMC: 8960011. DOI: 10.1155/2022/4136373. View

Shin D, Lee K . Dietary Acid Load Is Positively Associated with the Incidence of Hyperuricemia in Middle-Aged and Older Korean Adults: Findings from the Korean Genome and Epidemiology Study. Int J Environ Res Public Health. 2021; 18(19). PMC: 8508478. DOI: 10.3390/ijerph181910260. View

10.

Parohan M, Sadeghi A, Nasiri M, Maleki V, Khodadost M, Pirouzi A . Dietary acid load and risk of hypertension: A systematic review and dose-response meta-analysis of observational studies. Nutr Metab Cardiovasc Dis. 2019; 29(7):665-675. DOI: 10.1016/j.numecd.2019.03.009. View

11.

Li Q, Li X, Wang J, Liu H, Kwong J, Chen H . Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements. BMJ Open. 2019; 9(8):e026677. PMC: 6720466. DOI: 10.1136/bmjopen-2018-026677. View

12.

Liu L, Zhang X, Peng L, Ma N, Yang T, Nie C . Hyperuricemia is Related to the Risk of Cardiovascular Diseases in Ethnic Chinese Elderly Women. Glob Heart. 2022; 17(1):12. PMC: 8877644. DOI: 10.5334/gh.1102. View

13.

Liu R, Han C, Wu D, Xia X, Gu J, Guan H . Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis. Biomed Res Int. 2015; 2015:762820. PMC: 4657091. DOI: 10.1155/2015/762820. View

14.

Masulli M, DElia L, Angeli F, Barbagallo C, Bilancio G, Bombelli M . Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project. Nutr Metab Cardiovasc Dis. 2022; 32(5):1245-1252. DOI: 10.1016/j.numecd.2022.01.028. View

15.

Mohammadifard N, Karimi G, Khosravi A, Sarrafzadegan N, Jozan M, Zahed P . High dietary acid load score is not associated with the risk of metabolic syndrome in Iranian adults. Int J Vitam Nutr Res. 2020; 91(1-2):152-163. DOI: 10.1024/0300-9831/a000626. View

16.

Zhang L, An K, Mou X, Zhang M, Su Q, Li S . Effect of Urate-Lowering Therapy on the Progression of Kidney Function in Patients With Asymptomatic Hyperuricemia: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022; 12:795082. PMC: 8804353. DOI: 10.3389/fphar.2021.795082. View

17.

Kaneko K, Aoyagi Y, Fukuuchi T, Inazawa K, Yamaoka N . Total purine and purine base content of common foodstuffs for facilitating nutritional therapy for gout and hyperuricemia. Biol Pharm Bull. 2014; 37(5):709-21. DOI: 10.1248/bpb.b13-00967. View

18.

Wang M, Wang C, Zhao M, Li Y, Yao S, Wu S . Uric Acid Variability and All-Cause Mortality: A Prospective Cohort Study in Northern China. J Nutr Health Aging. 2021; 25(10):1235-1241. DOI: 10.1007/s12603-021-1706-3. View

19.

Dehlin M, Jacobsson L, Roddy E . Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020; 16(7):380-390. DOI: 10.1038/s41584-020-0441-1. View

20.

Huang L, Wang H, Wang Z, Zhang J, Zhang B, Ding G . Regional Disparities in the Association between Cereal Consumption and Metabolic Syndrome: Results from the China Health and Nutrition Survey. Nutrients. 2019; 11(4). PMC: 6521195. DOI: 10.3390/nu11040764. View