The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease

Overview

Journal Hematol Oncol Clin North Am

Specialties Hematology
Oncology

Date 2022 Nov 18

PMID 36400537

Authors

Kristie Ramos

Kristin P Guilliams

Melanie E Fields

Affiliations

Soon will be listed here.

Abstract

Sickle cell disease (SCD) is complicated by neurologic complications including vasculopathy, hemorrhagic or ischemic overt stroke, silent cerebral infarcts and cognitive dysfunction. Patients with SCD, even in the absence of vasculopathy or stroke, have experience cognitive dysfunction that progresses with age. Transcranial Doppler ultrasound and structural brain MRI are currently used for primary and secondary stroke prevention, but laboratory or imaging biomarkers do not currently exist that are specific to the risk of cognitive dysfunction in patients with SCD. Recent investigations have used advanced MR sequences assessing cerebral hemodynamics, white matter microstructure and functional connectivity to better understand the pathophysiology of cognitive decline in SCD, with the long-term goal of developing neuroimaging biomarkers to be used in risk prediction algorithms and to assess the efficacy of treatment options for patients with SCD.

Citing Articles

Role of Traditional Stroke Risk Factors Aiding in Prediction of Infarcts in Adult Patients With Sickle Cell Disease.

Garelnabi M, Parinandi N J Am Heart Assoc. 2024; 13(12):e034798.

PMID: 38842295 PMC: 11255737. DOI: 10.1161/JAHA.124.034798.

Neuroimaging and Cognitive Function in Sickle Cell Disease: A Systematic Review.

Abdi S, de Haan M, Kirkham F Children (Basel). 2023; 10(3).

PMID: 36980090 PMC: 10047189. DOI: 10.3390/children10030532.

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