Plasminogen-derived Peptide Promotes Adipogenic Differentiation of Preadipocytes and

Overview

Journal Adipocyte

Specialties Cell Biology
Endocrinology
Physiology

Date 2022 Nov 18

PMID 36397715

Authors

Hea Jung Yang

Jong-Ho Kim

Jung Hee Shim

Chan Yeong Heo

Affiliations

Soon will be listed here.

Abstract

Soft tissue defects caused by adipose tissue loss can result in various conditions such as lipodystrophy in congenital diseases, trauma secondary to ageing, and mastectomy in breast cancer; fat grafting is commonly performed to restore these defects. Although various enrichment strategies have been studied, novel therapeutics that are cost-effective, safe, technologically easy to manufacture, and minimally invasive are required. In this study, we identified a novel peptide derived from plasminogen, named plasminogen-derived peptide-1 (PLP-1), which showed adipogenic differentiation potential and led to an increase in the expression levels of adiponectin, C1Q and collagen domain containing protein, fatty acid-binding protein 4, and CCAAT/enhancer-binding protein-alpha. experiments confirmed an increase in the rate of adipocyte differentiation and the expression levels of CD31 in the PLP-1-treated mice groups. These results suggested that PLP-1 plays an important role in promoting the differentiation of preadipocytes and may be useful for developing therapeutic approaches to treat adipose tissue defects.

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