Diabetes and Skin Cancers: Risk Factors, Molecular Mechanisms and Impact on Prognosis

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2022 Nov 17

PMID 36387789

Authors

Elena-Codruta Dobrica

Madalina Laura Banciu

Vincent Kipkorir

Mohammad Amin Khazeei Tabari

Madeleine Jemima Cox

L V Simhachalam Kutikuppala

Mihnea-Alexandru Gaman

Affiliations

Soon will be listed here.

Abstract

Diabetes and skin cancers have emerged as threats to public health worldwide. However, their association has been less intensively studied. In this narrative review, we explore the common risk factors, molecular mechanisms, and prognosis of the association between cutaneous malignancies and diabetes. Hyperglycemia, oxidative stress, low-grade chronic inflammation, genetic, lifestyle, and environmental factors partially explain the crosstalk between skin cancers and this metabolic disorder. In addition, diabetes and its related complications may interfere with the appropriate management of cutaneous malignancies. Antidiabetic medication seems to exert an antineoplastic effect, however, future large, observation studies with a prospective design are needed to clarify its impact on the risk of malignancy in diabetes. Screening for diabetes in skin cancers, as well as close follow-up for the development of cutaneous malignancies in subjects suffering from diabetes, is warranted.

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