The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2022 Nov 17

PMID 36387746

Authors

Jing Zhang

Wentao Zhang

Tianze Sun

Jinzuo Wang

Ying Li

Jing Liu

Zhonghai Li

Affiliations

Soon will be listed here.

Abstract

Intervertebral disc degeneration is the main cause of low back pain. Traditional treatment methods cannot repair degenerated intervertebral disc tissue. The emergence of stem cell therapy makes it possible to regenerate and repair degenerated intervertebral disc tissue. At present, mesenchymal stem cells are the most studied, and different types of mesenchymal stem cells have their own characteristics. However, due to the harsh and complex internal microenvironment of the intervertebral disc, it will affect the biological behaviors of the implanted mesenchymal stem cells, such as viability, proliferation, migration, and chondrogenic differentiation, thereby affecting the therapeutic effect. This review is aimed at summarizing the influence of each intervertebral disc microenvironmental factor on the biological behavior of mesenchymal stem cells, so as to provide new ideas for using tissue engineering technology to assist stem cells to overcome the influence of the microenvironment in the future.

Citing Articles

Significance of Oxidative Stress in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration.

Gu J, Zhou X, Xie L Biochem Genet. 2023; 62(1):193-207.

PMID: 37314550 DOI: 10.1007/s10528-023-10412-x.

Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment.

Xia Y, Wang H, Yang R, Hou Y, Li Y, Zhu J Front Immunol. 2023; 14:1051606.

PMID: 36756124 PMC: 9900107. DOI: 10.3389/fimmu.2023.1051606.

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