Biophysical Insights into the Binding Capability of Cu(II) Schiff Base Complex with BSA Protein and Cytotoxicity Studies Against SiHa

Overview

Journal Heliyon

Specialty Social Sciences

Date 2022 Nov 17

PMID 36387430

Authors

Minakshi Maity

Ushasi Pramanik

Venkatesha R Hathwar

Paula Brandao

Saptarshi Mukherjee

Swapan Maity

Ribhu Maity

Tithi Maity

Bidhan Chandra Samanta

Affiliations

Soon will be listed here.

Abstract

Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma.

References

Ng C, Kong K, Von S, Balraj P, Jensen P, Thirthagiri E . Synthesis, characterization, DNA-binding study and anticancer properties of ternary metal(II) complexes of edda and an intercalating ligand. Dalton Trans. 2008; (4):447-54. DOI: 10.1039/b709269e. View

Jaouen G, Vessieres A, Top S . Ferrocifen type anti cancer drugs. Chem Soc Rev. 2015; 44(24):8802-17. DOI: 10.1039/c5cs00486a. View

Yoshida D, Ikeda Y, Nakazawa S . Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors. J Neurooncol. 1993; 16(2):109-15. DOI: 10.1007/BF01324697. View

Rustgi A . The genetics of hereditary colon cancer. Genes Dev. 2007; 21(20):2525-38. DOI: 10.1101/gad.1593107. View

Sava G, Clerici K, Capozzi I, Cocchietto M, Gagliardi R, Alessio E . Reduction of lung metastasis by ImH[trans-RuCl4(DMSO)Im]: mechanism of the selective action investigated on mouse tumors. Anticancer Drugs. 1999; 10(1):129-38. DOI: 10.1097/00001813-199901000-00016. View

Cocchietto M, Sava G . Blood concentration and toxicity of the antimetastasis agent NAMI-A following repeated intravenous treatment in mice. Pharmacol Toxicol. 2000; 87(5):193-7. DOI: 10.1034/j.1600-0773.2000.d01-73.x. View

Hotze A, Caspers S, de Vos D, Kooijman H, Spek A, Flamigni A . Structure-dependent in vitro cytotoxicity of the isomeric complexes [Ru(L)2Cl2] (L= o-tolylazopyridine and 4-methyl-2-phenylazopyridine) in comparison to [Ru(azpy)2Cl2]. J Biol Inorg Chem. 2004; 9(3):354-64. DOI: 10.1007/s00775-004-0531-6. View

Bales B, Kodama T, Weledji Y, Pitie M, Meunier B, Greenberg M . Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates. Nucleic Acids Res. 2005; 33(16):5371-9. PMC: 1235636. DOI: 10.1093/nar/gki856. View

Augusto Chaves O, de Castro I, Goulart C, Bellieny M, Netto-Ferreira J, Echevarria-Lima J . In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone. Invest New Drugs. 2019; 37(5):994-1005. DOI: 10.1007/s10637-018-00722-y. View

10.

Maheswari P, Roy S, den Dulk H, Barends S, van Wezel G, Kozlevcar B . The square-planar cytotoxic [Cu(II)(pyrimol)Cl] complex acts as an efficient DNA cleaver without reductant. J Am Chem Soc. 2006; 128(3):710-1. DOI: 10.1021/ja056970+. View

11.

Margiotta N, Natile G, Capitelli F, Fanizzi F, Boccarelli A, De Rinaldis P . Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance. J Inorg Biochem. 2006; 100(11):1849-57. DOI: 10.1016/j.jinorgbio.2006.07.010. View

12.

Islami F, Sauer A, Miller K, Siegel R, Fedewa S, Jacobs E . Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 2017; 68(1):31-54. DOI: 10.3322/caac.21440. View

13.

Maity R, Sepay N, Pramanik U, Jana K, Mukherjee S, Maity S . Exploring the Noncovalent Interactions of the Dinuclear Cu(II) Schiff Base Complex with Bovine Serum Albumin and Cell Viability against the SiHa Cancer Cell Line. J Phys Chem B. 2021; 125(41):11364-11373. DOI: 10.1021/acs.jpcb.1c05794. View

14.

Turecky L, Kalina P, Uhlikova E, Namerova S, KRIZKO J . Serum ceruloplasmin and copper levels in patients with primary brain tumors. Klin Wochenschr. 1984; 62(4):187-9. DOI: 10.1007/BF01731643. View

15.

Kosa T, Maruyama T, Otagiri M . Species differences of serum albumins: I. Drug binding sites. Pharm Res. 1998; 14(11):1607-12. DOI: 10.1023/a:1012138604016. View

16.

Hartinger C, Zorbas-Seifried S, Jakupec M, Kynast B, Zorbas H, Keppler B . From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A). J Inorg Biochem. 2006; 100(5-6):891-904. DOI: 10.1016/j.jinorgbio.2006.02.013. View

17.

Morris R, Aird R, Murdoch P, Chen H, Cummings J, Hughes N . Inhibition of cancer cell growth by ruthenium(II) arene complexes. J Med Chem. 2001; 44(22):3616-21. DOI: 10.1021/jm010051m. View

18.

Pramanik U, Kongasseri A, Shekhar S, Mathew A, Yadav R, Mukherjee S . Structural Compactness in Hen Egg White Lysozyme Induced by Bisphenol S: A Spectroscopic and Molecular Dynamics Simulation Approach. Chemphyschem. 2021; 22(17):1745-1753. DOI: 10.1002/cphc.202100272. View

19.

Barbara C, Orlandi P, Bocci G, Fioravanti A, Di Paolo A, Natale G . In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatoma. Eur J Pharmacol. 2006; 549(1-3):27-34. DOI: 10.1016/j.ejphar.2006.08.015. View

20.

Bertrand B, Casini A . A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds. Dalton Trans. 2013; 43(11):4209-19. DOI: 10.1039/c3dt52524d. View