The Mechanism of Bone Repair: Stem Cells in the Periosteum Dedicated to Bridging a Large Gap
Overview
General Medicine
Authors
Affiliations
Bone repair requires the mobilization of stem cells from outer periosteum and inner bone marrow. A study by Jeffery et al. shows that periosteal stem cells are dedicated to repairing a large defect and regenerating both bone and marrow stroma.
Weldon K, Longaker M, Ambrosi T Stem Cells. 2025; 43(3).
PMID: 39945760 PMC: 11892563. DOI: 10.1093/stmcls/sxaf006.
Hwa S, Lee H, Ko Y, Park J Medicina (Kaunas). 2025; 61(1).
PMID: 39859058 PMC: 11766960. DOI: 10.3390/medicina61010076.
Tenascin-C promotes bone regeneration via inflammatory macrophages.
Ren Q, Xing W, Jiang B, Feng H, Hu X, Suo J Cell Death Differ. 2025; .
PMID: 39794452 DOI: 10.1038/s41418-024-01429-9.
Requirement of Pdgfrα+ cells for calvarial bone repair.
Xing X, Li Z, Xu J, Chen A, Archer M, Wang Y Stem Cells Transl Med. 2024; 13(8):791-802.
PMID: 38986535 PMC: 11328938. DOI: 10.1093/stcltm/szae041.
The Role of Stem Cells in the Treatment of Cardiovascular Diseases.
Bakinowska E, Kielbowski K, Boboryko D, Bratborska A, Olejnik-Wojciechowska J, Rusinski M Int J Mol Sci. 2024; 25(7).
PMID: 38612710 PMC: 11011548. DOI: 10.3390/ijms25073901.