Protective Effect of Tisochrysis Lutea on Dry Eye Syndrome Via NF-κB Inhibition

Overview

Journal Sci Rep

Specialty Science

Date 2022 Nov 15

PMID 36380046

Authors

Sung-Chul Hong

Hyung Seok Yu

Jin-Woo Kim

Eun Ha Lee

Cheol-Ho Pan

Kwang Won Hong

Jin-Chul Kim

Affiliations

Soon will be listed here.

Abstract

Dry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown. DES is characterized by a decrease in corneal thickness, tear volume, and lacrimal gland size, and damage to corneal cells. Tisochrysis lutea is a microalga that has been shown to reduce immune factors. Therefore, we hypothesized that T. lutea could ameliorate DES. We investigated the role of T. lutea in scopolamine-induced DES in BALB/c mice. Oral administration of T. lutea increased corneal thickness, tear volume, and size of the corneal cells, and reduced damage to the corneal cells. Furthermore, treatment of ARPE-19 human retinal pigmented epithelial cells with T. lutea reduced expression of the inflammatory factor, NF-κB, MAPK, and AKT. T. lutea may be used therapeutically to reduce the symptoms of DES.

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References

Li M, Gong L, Sun X, Chapin W . Anxiety and depression in patients with dry eye syndrome. Curr Eye Res. 2010; 36(1):1-7. DOI: 10.3109/02713683.2010.519850. View

Kawai T, Akira S . Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007; 13(11):460-9. DOI: 10.1016/j.molmed.2007.09.002. View

Kwiatkowska B, Maslinska M . The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases. Reumatologia. 2020; 58(1):34-41. PMC: 7174795. DOI: 10.5114/reum.2020.93511. View

Zhu W, Wu Y, Li G, Wang J, Li X . Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta-analysis of randomized controlled trials. Nutr Rev. 2014; 72(10):662-71. DOI: 10.1111/nure.12145. View

Smith G, Julliand S, Reeds D, Sinacore D, Klein S, Mittendorfer B . Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015; 102(1):115-22. PMC: 4480667. DOI: 10.3945/ajcn.114.105833. View

Lopez-Miguel A, Teson M, Martin-Montanez V, Enriquez-de-Salamanca A, Stern M, Calonge M . Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. Am J Ophthalmol. 2014; 157(4):788-798.e2. DOI: 10.1016/j.ajo.2014.01.001. View

Simopoulos A . The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002; 56(8):365-79. DOI: 10.1016/s0753-3322(02)00253-6. View

Lotrich F, Sears B, McNamara R . Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6. Brain Behav Immun. 2012; 31:48-53. PMC: 3552059. DOI: 10.1016/j.bbi.2012.08.007. View

Javadi M, Feizi S . Dry eye syndrome. J Ophthalmic Vis Res. 2012; 6(3):192-8. PMC: 3306104. View

10.

Buoite Stella A, Gortan Cappellari G, Barazzoni R, Zanetti M . Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review. Int J Mol Sci. 2018; 19(1). PMC: 5796167. DOI: 10.3390/ijms19010218. View

11.

Saha R, Jana M, Pahan K . MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol. 2007; 179(10):7101-9. PMC: 2701546. DOI: 10.4049/jimmunol.179.10.7101. View

12.

Schneider C, Rasband W, Eliceiri K . NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012; 9(7):671-5. PMC: 5554542. DOI: 10.1038/nmeth.2089. View

13.

McCabe E, Narayanan S . Advancements in anti-inflammatory therapy for dry eye syndrome. Optometry. 2009; 80(10):555-66. DOI: 10.1016/j.optm.2009.02.010. View

14.

Simopoulos A . The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac J Clin Nutr. 2008; 17 Suppl 1:131-4. View

15.

Wallace J, McCabe A, Robson P, Keogh M, Murray C, Kelly P . Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil. Ann Nutr Metab. 2000; 44(4):157-62. DOI: 10.1159/000012839. View

16.

Daull P, Amrane M, Ismail D, Georgiev G, Cwiklik L, Baudouin C . Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease. J Ocul Pharmacol Ther. 2020; 36(6):355-365. PMC: 7404832. DOI: 10.1089/jop.2020.0011. View

17.

Valim V, Trevisani V, Sousa J, Vilela V, Belfort Jr R . Current Approach to Dry Eye Disease. Clin Rev Allergy Immunol. 2014; 49(3):288-97. DOI: 10.1007/s12016-014-8438-7. View

18.

Hom M, Asbell P, Barry B . Omegas and Dry Eye: More Knowledge, More Questions. Optom Vis Sci. 2015; 92(9):948-56. DOI: 10.1097/OPX.0000000000000655. View

19.

Colligris B, Alkozi H, Pintor J . Recent developments on dry eye disease treatment compounds. Saudi J Ophthalmol. 2014; 28(1):19-30. PMC: 3923205. DOI: 10.1016/j.sjopt.2013.12.003. View

20.

Galor A, Zlotcavitch L, Walter S, Felix E, Feuer W, Martin E . Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain. Br J Ophthalmol. 2014; 99(5):665-8. DOI: 10.1136/bjophthalmol-2014-306057. View