Topological Implications of DNA Tumor Viral Episomes

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2022 Nov 15

PMID 36379513

Authors

Eui Tae Kim

Kyoung-Dong Kim

Affiliations

Soon will be listed here.

Abstract

A persistent DNA tumor virus infection transforms normal cells into cancer cells by either integrating its genome into host chromosomes or retaining it as an extrachromosomal entity called episome. Viruses have evolved mechanisms for attaching episomes to infected host cell chromatin to efficiently segregate the viral genome during mitosis. It has been reported that viral episome can affect the gene expression of the host chromosomes through interactions between viral episomes and epigenetic regulatory host factors. This mini review summarizes our current knowledge of the tethering sites of viral episomes, such as EBV, KSHV, and HBV, on host chromosomes analyzed by three-dimensional genomic tools. [BMB Reports 2022; 55(12): 587-594].

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