Evaluation of an I177L Gene-based Five-gene-deleted African Swine Fever Virus As a Live Attenuated Vaccine in Pigs

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2022 Nov 15

PMID 36378022

Authors

Yingnan Liu

Zhenhua Xie

Yao Li

Yingying Song

Dongdong Di

Jingyi Liu

Lang Gong

Zongyan Chen

Jinxian Wu

Zhengqin Ye

Jianqi Liu

Wanqi Yu

Lu Lv

Qiuping Zhong

Chuanwen Tian

Qingqing Song

Heng Wang

Hongjun Chen

Affiliations

Soon will be listed here.

Abstract

African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to produce reliable immunity. As a result, a genetically engineered virus containing five genes deletion was synthesized based on ASFV Chinese strain GZ201801, named ASFV-GZΔI177LΔCD2vΔMGF. The five-gene-deleted ASFV was safe and fully attenuated in pigs and provides reliable protection against the parental ASFV strain challenge. This indicates that the five-gene-deleted ASFV is a potential candidate for a live attenuated vaccine that could control the spread of ASFV.

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