Developmental Changes of the Fetal and Neonatal Thyroid Gland and Functional Consequences on the Cardiovascular System

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2022 Nov 14

PMID 36376450

Authors

Ioanna Kotsopoulou

Arpita K Vyas

Melinda J Cory

Christina S Chan

Jawahar Jagarapu

Shamaila Gill

Manjula Mudduluru

Dimitrios Angelis

Affiliations

Soon will be listed here.

Abstract

Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.

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