CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Nov 11

PMID 36366543

Authors

Noha Mousaad Elemam

Iman Mamdouh Talaat

Azzam A Maghazachi

Affiliations

Soon will be listed here.

Abstract

Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of chemokine expression helps shape the immune response and regulate viral clearance, improving clinical outcome. In particular, the chemokine ligand CXCL10 and its receptor CXCR3 were explored in a plethora of RNA and DNA viral infections. In this review, we highlight the expression profile and role of the CXCL10/CXCR3 axis in the host defense against a variety of RNA and DNA viral infections. We also discuss the interactions among viruses and host cells that trigger CXCL10 expression, as well as the signaling cascades induced in CXCR3 positive cells.

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