» Articles » PMID: 36366409

The Impact and Progression of the COVID-19 Pandemic in Bulgaria in Its First Two Years

Overview
Date 2022 Nov 11
PMID 36366409
Authors
Affiliations
Soon will be listed here.
Abstract

After initially having low levels of SARS-CoV-2 infections for much of the year, Bulgaria experienced a major epidemic surge at the end of 2020, which caused the highest recorded excess mortality in Europe, among the highest in the word (Excess Mortality Rate, or EMR ∼0.25%). Two more major waves followed in 2021, followed by another one in early 2022. In this study, we analyze the temporal and spatial patterns of excess mortality at the national and local levels and across different demographic groups in Bulgaria and compare those to the European levels. Bulgaria has continued to exhibit the previous pattern of extremely high excess mortality, as measured both by crude mortality metrics (an EMR of ∼1.05%, up to the end of March 2022) and by standardized ones-Potential Years of Life Lost (PYLL) and Aged-Standardized Years of life lost Rate (ASYR). Unlike Western Europe, the bulk of excess mortality in Bulgaria, as well as in several other countries in Eastern Europe, occurred in the second year of the pandemic, likely related to the differences in the levels of vaccination coverage between these regions. We also observe even more extreme levels of excess mortality at the regional level and in some subpopulations (e.g., total EMR values for males ≥ 2% and EMR values for males aged 40-64 ≥ 1% in certain areas). We discuss these observations in light of the estimates of infection fatality rate (IFR) and eventual population fatality rate (PFR) made early in the course of the pandemic.

Citing Articles

Family Dynamics, Socioeconomic Hardships, and Health Risk Behaviours of Bulgarian Adolescents during the COVID-19 Pandemic.

Dimitrova E, Alexandrova-Karamanova A Children (Basel). 2024; 11(8).

PMID: 39201950 PMC: 11352231. DOI: 10.3390/children11081016.


Premature Mortality Excess Rates Before and During the COVID-19 Pandemic: A Comparative Analysis Conducted in Bihor County, Romania.

Rahota D, Rahota R, Camarasan A, Muresan M, Magheru S, Rahota D Cureus. 2024; 16(5):e60403.

PMID: 38883066 PMC: 11179132. DOI: 10.7759/cureus.60403.


Disparities and effectiveness of COVID-19 vaccine policies in three representative European countries.

Xie W, Shi L, Liu M, Yang J, Ma M, Sun G Int J Equity Health. 2024; 23(1):16.

PMID: 38287322 PMC: 10825987. DOI: 10.1186/s12939-024-02110-w.


Genomic Epidemiology and Lineage Dynamics of SARS-CoV-2 in Bulgaria: Insights from a Three-Year Pandemic Analysis.

Giovanetti M, Cella E, Ivanov I, Grigorova L, Stoikov I, Donchev D Viruses. 2023; 15(9).

PMID: 37766330 PMC: 10536935. DOI: 10.3390/v15091924.


Relative Risk of Death in Bulgarian Cancer Patients during the Initial Waves of the COVID-19 Pandemic.

Shivarov V, Grigorova D, Yordanov A Healthcare (Basel). 2023; 11(18).

PMID: 37761791 PMC: 10531457. DOI: 10.3390/healthcare11182594.


References
1.
Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

2.
Murison K, Grima A, Simmons A, Tuite A, Fisman D . Severity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Pregnancy in Ontario: A Matched Cohort Analysis. Clin Infect Dis. 2022; 76(3):e200-e206. PMC: 9907552. DOI: 10.1093/cid/ciac544. View

3.
Yamasoba D, Kimura I, Nasser H, Morioka Y, Nao N, Ito J . Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. Cell. 2022; 185(12):2103-2115.e19. PMC: 9057982. DOI: 10.1016/j.cell.2022.04.035. View

4.
Molenberghs G, Faes C, Verbeeck J, Deboosere P, Abrams S, Willem L . COVID-19 mortality, excess mortality, deaths per million and infection fatality ratio, Belgium, 9 March 2020 to 28 June 2020. Euro Surveill. 2022; 27(7). PMC: 8855510. DOI: 10.2807/1560-7917.ES.2022.27.7.2002060. View

5.
Rangachev A, Marinov G, Mladenov M . The demographic and geographic impact of the COVID pandemic in Bulgaria and Eastern Europe in 2020. Sci Rep. 2022; 12(1):6333. PMC: 9012259. DOI: 10.1038/s41598-022-09790-w. View