Evidence of the Beneficial Effects of Ursolic Acid Against Lung Cancer

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Nov 11

PMID 36364289

Authors

Amanda Kornel

Matteo Nadile

Evangelia Tsiani

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the leading cause of cancer-related deaths globally. Despite current treatment approaches that include surgery, chemotherapy, radiation and immunotherapies, lung cancer accounted for 1.79 million deaths worldwide in 2020, emphasizing the urgent need to find novel agents and approaches for more effective treatment. Traditionally, chemicals derived from plants, such as paclitaxel and docetaxel, have been used in cancer treatment, and in recent years, research has focused on finding other plant-derived chemicals that can be used in the fight against lung cancer. Ursolic acid is a polyphenol found in high concentrations in cranberries and other fruits and has been demonstrated to have anti-inflammatory, antioxidant and anticancer properties. In this review, we summarize recent research examining the effects of ursolic acid and its derivatives on lung cancer. Data from in vitro cell culture and in vivo animal studies show potent anticancer effects of ursolic acid and indicate the need for clinical studies.

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References

Passaro A, Brahmer J, Antonia S, Mok T, Peters S . Managing Resistance to Immune Checkpoint Inhibitors in Lung Cancer: Treatment and Novel Strategies. J Clin Oncol. 2022; 40(6):598-610. DOI: 10.1200/JCO.21.01845. View

Mlala S, Oyedeji A, Gondwe M, Oyedeji O . Ursolic Acid and Its Derivatives as Bioactive Agents. Molecules. 2019; 24(15). PMC: 6695944. DOI: 10.3390/molecules24152751. View

Guertin D, Sabatini D . Defining the role of mTOR in cancer. Cancer Cell. 2007; 12(1):9-22. DOI: 10.1016/j.ccr.2007.05.008. View

Nooreldeen R, Bach H . Current and Future Development in Lung Cancer Diagnosis. Int J Mol Sci. 2021; 22(16). PMC: 8395394. DOI: 10.3390/ijms22168661. View

Lin Y, Liang W, Chen C, Tsang H, Chiou J, Liu X . Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells. Phytomedicine. 2019; 58:152893. DOI: 10.1016/j.phymed.2019.152893. View

Li X, Wang T, Zhou B, Gao W, Cao J, Huang L . Chemical composition and antioxidant and anti-inflammatory potential of peels and flesh from 10 different pear varieties (Pyrus spp.). Food Chem. 2014; 152:531-8. DOI: 10.1016/j.foodchem.2013.12.010. View

Yip H, Papa A . Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments. Cells. 2021; 10(3). PMC: 8002322. DOI: 10.3390/cells10030659. View

Kim S, Ryu H, Lee J, Shin J, Harikishore A, Jung H . Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Sci Rep. 2015; 5:14570. PMC: 4585938. DOI: 10.1038/srep14570. View

Seo D, Lee S, Heo J, No M, Rhee B, Ko K . Ursolic acid in health and disease. Korean J Physiol Pharmacol. 2018; 22(3):235-248. PMC: 5928337. DOI: 10.4196/kjpp.2018.22.3.235. View

10.

Gao Y, Yuan Y, Song G, Lin S . Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo. Genet Mol Res. 2016; 15(2). DOI: 10.4238/gmr.15028642. View

11.

Butkeviciute A, Viskelis J, Liaudanskas M, Viskelis P, Bobinas C, Janulis V . Variation of Triterpenes in Apples Stored in a Controlled Atmosphere. Molecules. 2021; 26(12). PMC: 8232341. DOI: 10.3390/molecules26123639. View

12.

Dar B, Lone A, Shah W, Qurishi M . Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents. Eur J Med Chem. 2016; 111:26-32. DOI: 10.1016/j.ejmech.2016.01.026. View

13.

Kang D, Sp N, Lee J, Jang K . Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells. Biomedicines. 2021; 9(3). PMC: 7998465. DOI: 10.3390/biomedicines9030297. View

14.

Wozniak L, Skapska S, Marszalek K . Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. Molecules. 2015; 20(11):20614-41. PMC: 6332387. DOI: 10.3390/molecules201119721. View

15.

Khwaza V, Oyedeji O, Aderibigbe B . Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update. Int J Mol Sci. 2020; 21(16). PMC: 7460570. DOI: 10.3390/ijms21165920. View

16.

Yang K, Chen Y, Zhou J, Ma L, Shan Y, Cheng X . Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. Br J Pharmacol. 2019; 176(24):4609-4624. PMC: 6965687. DOI: 10.1111/bph.14793. View

17.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

18.

Zou J, Lin J, Li C, Zhao R, Fan L, Yu J . Ursolic Acid in Cancer Treatment and Metastatic Chemoprevention: From Synthesized Derivatives to Nanoformulations in Preclinical Studies. Curr Cancer Drug Targets. 2018; 19(4):245-256. DOI: 10.2174/1568009618666181016145940. View

19.

Arbour K, Riely G . Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review. JAMA. 2019; 322(8):764-774. DOI: 10.1001/jama.2019.11058. View

20.

Shaw R, Cantley L . Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006; 441(7092):424-30. DOI: 10.1038/nature04869. View