Polymorphism and Genetic Predisposition to T1D in Jordanian Patients: A Case-Control Study

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Nov 11

PMID 36362968

Authors

Wassan Jarrar

Sawsan I Khdair

Feras A Khudeir

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes (T1D) is an autoimmune disorder whose etiology includes genetic and environmental factors. The non-classical Major Histocompatibility Complex (MHC) class I chain-related gene A ( gene has been associated with increased susceptibility to T1D as the interaction of MICA to the Natural Killer Group 2D (NK2GD) receptors found on the cell surface of natural killer (NK) cells and T cells is responsible for inducing immune responses. polymorphisms were reported in association with T1D among different ethnic groups. However, data from different populations revealed conflicting results, so the association of polymorphisms with predisposition to T1D remains uncertain. The aim of this sequencing-based study was to identify, for the first time, the possible alleles and/or genotypes that could be associated with T1D susceptibility in the Jordanian population. Polymorphisms in exons 2-4 and the short tandem repeats (STR) in exon 5 of the highly polymorphic gene were analyzed. No evidence for association between T1D and alleles/genotypes was found in this study, except for the allele which was found to be negatively associated with T1D ( = 0.023, OR = 0.125). In conclusion, polymorphisms seem not to be associated with increasing T1D susceptibility in Jordanian patients.

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