National Trends in Prevalence of Depression in Men and Women with Chronic Obstructive Pulmonary Disease Hospitalized in Spain, 2016-2020

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Nov 11

PMID 36362570

Authors

Javier de Miguel-Diez

Ana Lopez-de-Andres

Rodrigo Jimenez-Garcia

Jose M De Miguel-Yanes

Valentin Hernandez-Barrera

David Carabantes-Alarcon

Jose J Zamorano-Leon

Concepcion Noriega

Affiliations

Soon will be listed here.

Abstract

(1) Background: To describe trends in the prevalence of depression in men and women with COPD hospitalized in Spain (2016-2020). (2) Methods: We used a nationwide discharge database to select all patients ≥35 years with COPD. (3) Results: The prevalence of depression was 3.54-times higher in women with COPD than in men (OR 3.54; 95%CI 3.48-3.6). It decreased significantly between 2016 and 2020, although the reduction was only significant in women (12.27% in 2016 vs. 10.56% in 2020). Older age, comorbidity and the most recent years of hospital admission were associated with lower prevalence of depression in both men and women, while obesity, obstructive sleep apnea (OSA) and use of oxygen prior to admission were risk factors. In-hospital mortality (IHM) increased significantly over time. Older age, comorbidity, the use of oxygen prior to admission and having been hospitalized in 2020 increased the risk of IHM. Female sex was associated with a lower IHM in patients with depression and COPD. (4) Conclusions: The prevalence of depression has decreased over time in women with COPD while it has not changed significantly in men with this disease. IHM increased over time both in men and women with COPD and depression, with higher prevalence in the former.

References

Zhao Z, Zhang D, Sun H, Chang D, Lv X, Lin J . Anxiety and depression in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Sleep Breath. 2021; 26(4):1603-1611. DOI: 10.1007/s11325-021-02500-2. View

Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik M, Yohannes A . Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest. 2008; 134(4 Suppl):43S-56S. PMC: 2849676. DOI: 10.1378/chest.08-0342. View

Menear M, Dore I, Cloutier A, Perrier L, Roberge P, Duhoux A . The influence of comorbid chronic physical conditions on depression recognition in primary care: a systematic review. J Psychosom Res. 2015; 78(4):304-13. DOI: 10.1016/j.jpsychores.2014.11.016. View

Fuentes-Alonso M, Lopez-Herranz M, Lopez-de-Andres A, Ji Z, Jimenez-Garcia R, Maestre-Miquel C . Prevalence and Determinants of Mental Health among COPD Patients in a Population-Based Sample in Spain. J Clin Med. 2021; 10(13). PMC: 8268632. DOI: 10.3390/jcm10132786. View

Vikjord S, Brumpton B, Mai X, Vanfleteren L, Langhammer A . The association of anxiety and depression with mortality in a COPD cohort. The HUNT study, Norway. Respir Med. 2020; 171:106089. DOI: 10.1016/j.rmed.2020.106089. View

Barrueco-Otero E, Refoyo Matellan B, Martin Puente J, Vinado Manes C, Leon Subias E, Olivera Pueyo J . [Prevalence of Depressive Symptoms, Predictive Factors, and Diagnosis of Suspicion of Depression in Patients with COPD]. Aten Primaria. 2022; 54(3):102236. PMC: 8841611. DOI: 10.1016/j.aprim.2021.102236. View

Kessler R, Birnbaum H, Bromet E, Hwang I, Sampson N, Shahly V . Age differences in major depression: results from the National Comorbidity Survey Replication (NCS-R). Psychol Med. 2009; 40(2):225-37. PMC: 2813515. DOI: 10.1017/S0033291709990213. View

Wu D, Zhao X, Huang D, Dai Z, Chen M, Li D . Outcomes associated with comorbid anxiety and depression among patients with stable COPD: A patient registry study in China. J Affect Disord. 2022; 313:77-83. DOI: 10.1016/j.jad.2022.06.059. View

Laurin C, Lavoie K, Bacon S, Dupuis G, Lacoste G, Cartier A . Sex differences in the prevalence of psychiatric disorders and psychological distress in patients with COPD. Chest. 2007; 132(1):148-55. DOI: 10.1378/chest.07-0134. View

10.

Matte D, Pizzichini M, Hoepers A, Diaz A, Karloh M, Dias M . Prevalence of depression in COPD: A systematic review and meta-analysis of controlled studies. Respir Med. 2016; 117:154-61. DOI: 10.1016/j.rmed.2016.06.006. View

11.

Akhtar-Danesh N, Landeen J . Relation between depression and sociodemographic factors. Int J Ment Health Syst. 2008; 1(1):4. PMC: 2241832. DOI: 10.1186/1752-4458-1-4. View

12.

Vin-Raviv N, Akinyemiju T, Galea S, Bovbjerg D . Depression and Anxiety Disorders among Hospitalized Women with Breast Cancer. PLoS One. 2015; 10(6):e0129169. PMC: 4452789. DOI: 10.1371/journal.pone.0129169. View

13.

Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N . Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med. 2015; 3(4):310-8. PMC: 4404207. DOI: 10.1016/S2213-2600(15)00043-0. View

14.

Zhang M, Ho R, Cheung M, Fu E, Mak A . Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and meta-regression. Gen Hosp Psychiatry. 2011; 33(3):217-23. DOI: 10.1016/j.genhosppsych.2011.03.009. View

15.

Pino E, Zuo Y, Borba C, Henderson D, Kalesan B . Clinical depression and anxiety among ST-elevation myocardial infarction hospitalizations: Results from Nationwide Inpatient Sample 2004-2013. Psychiatry Res. 2018; 266:291-300. DOI: 10.1016/j.psychres.2018.03.025. View

16.

Blakemore A, Dickens C, Chew-Graham C, Afzal C, Tomenson B, Coventry P . Depression predicts emergency care use in people with chronic obstructive pulmonary disease: a large cohort study in primary care. Int J Chron Obstruct Pulmon Dis. 2019; 14:1343-1353. PMC: 6607976. DOI: 10.2147/COPD.S179109. View

17.

Di Marco F, Verga M, Reggente M, Maria Casanova F, Santus P, Blasi F . Anxiety and depression in COPD patients: The roles of gender and disease severity. Respir Med. 2006; 100(10):1767-74. DOI: 10.1016/j.rmed.2006.01.026. View

18.

Docherty J . Barriers to the diagnosis of depression in primary care. J Clin Psychiatry. 1997; 58 Suppl 1:5-10. View

19.

Miravitlles M, Molina J, Quintano J, Campuzano A, Perez J, Roncero C . Factors associated with depression and severe depression in patients with COPD. Respir Med. 2014; 108(11):1615-25. DOI: 10.1016/j.rmed.2014.08.010. View

20.

Meza D, Khuder B, Bailey J, Rosenberg S, Kalhan R, Reyfman P . Mortality from COVID-19 in Patients with COPD: A US Study in the N3C Data Enclave. Int J Chron Obstruct Pulmon Dis. 2021; 16:2323-2326. PMC: 8370846. DOI: 10.2147/COPD.S318000. View