The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Nov 11

PMID 36362020

Authors

Martyna Tomczyk-Socha

Wojciech Tomczak

Anna Turno-Krecicka

Affiliations

Soon will be listed here.

Abstract

Pseudoexfoliation syndrome (PEX) is an important systemic disorder of the extracellular matrix, in which granular amyloid-like protein fibers accumulate in the anterior segment of the eyeball as well as in other organs. PEX is currently considered to be a multifactorial systemic disorder with genetic and environmental risk factors. The aim of this manuscript was to analyze miR expression in PEX. In recent years, an attempt has been made to investigate and describe the level of expression of selected miRs in PEX. Four polymorphisms of genes isolated from the blood that may be related to PEX were identified and miR-122-5p was found to be upregulated in patient blood. Furthermore, 18 miRs were identified with a statistically different expression in the aqueous humor. A significantly elevated expression of miR-125b was found in the anterior lens capsule, and four miRs were described, which may have a significant impact on the development of PEX. Regulatory miR molecules are gaining more and more importance in research aimed at identifying and isolating molecular markers related to the pathogenesis and prognosis of PEX, but further studies are needed.

Citing Articles

Associations Between Epigenetic Age Acceleration and microRNA Expression Among U.S. Firefighters.

Jung A, Furlong M, Goodrich J, Cardenas A, Beitel S, Littau S Epigenet Insights. 2023; 16:25168657231206301.

PMID: 37953967 PMC: 10634256. DOI: 10.1177/25168657231206301.

Pseudoexfoliation Syndrome-Clinical Characteristics of Most Common Cause of Secondary Glaucoma.

Tomczyk-Socha M, Tomczak W, Winkler-Lach W, Turno-Krecicka A J Clin Med. 2023; 12(10).

PMID: 37240686 PMC: 10218815. DOI: 10.3390/jcm12103580.

Corneal optical density: Structural basis, measurements, influencing factors, and roles in refractive surgery.

He Y, Ma B, Zeng J, Ma D Front Bioeng Biotechnol. 2023; 11:1144455.

PMID: 37091331 PMC: 10117965. DOI: 10.3389/fbioe.2023.1144455.

References

Khee S, Mohd Yusof Y, Makpol S . Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid Med Cell Longev. 2014; 2014:725929. PMC: 4123634. DOI: 10.1155/2014/725929. View

Lee Y, Jeon K, Lee J, Kim S, Kim V . MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002; 21(17):4663-70. PMC: 126204. DOI: 10.1093/emboj/cdf476. View

Weber J, Baxter D, Zhang S, Huang D, Huang K, Lee M . The microRNA spectrum in 12 body fluids. Clin Chem. 2010; 56(11):1733-41. PMC: 4846276. DOI: 10.1373/clinchem.2010.147405. View

Tabak S, Schreiber-Avissar S, Beit-Yannai E . Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma. Int J Mol Sci. 2021; 22(5). PMC: 7957693. DOI: 10.3390/ijms22052421. View

Seland J . The ultrastructure of the deep layer of the lens capsule in fibrillopathia epitheliocapsularis (FEC), so-called senile exfoliation or pseudoexfoliation. A scanning electron microscopic study. Acta Ophthalmol (Copenh). 1978; 56(3):335-48. DOI: 10.1111/j.1755-3768.1978.tb05686.x. View

Guo R, Shen W, Su C, Jiang S, Wang J . Relationship between the Pathogenesis of Glaucoma and miRNA. Ophthalmic Res. 2017; 57(3):194-199. DOI: 10.1159/000450957. View

Peng C, Liu J, Woung L, Lin T, Chiou S, Tseng P . MicroRNAs and cataracts: correlation among let-7 expression, age and the severity of lens opacity. Br J Ophthalmol. 2012; 96(5):747-51. DOI: 10.1136/bjophthalmol-2011-300585. View

Shomron N, Levy C . MicroRNA-biogenesis and Pre-mRNA splicing crosstalk. J Biomed Biotechnol. 2009; 2009:594678. PMC: 2709726. DOI: 10.1155/2009/594678. View

Damji K, Bains H, Stefansson E, Loftsdottir M, Sverrisson T, Thorgeirsson E . Is pseudoexfoliation syndrome inherited? A review of genetic and nongenetic factors and a new observation. Ophthalmic Genet. 1999; 19(4):175-85. DOI: 10.1076/opge.19.4.175.2310. View

10.

G Hindle A, Thoonen R, Jasien J, Grange R, Amin K, Wise J . Identification of Candidate miRNA Biomarkers for Glaucoma. Invest Ophthalmol Vis Sci. 2019; 60(1):134-146. PMC: 6329203. DOI: 10.1167/iovs.18-24878. View

11.

Grenda A, Budzynski M, Filip A . [Biogenesis of microRNAs and their role in the development and course of selected hematologic disorders]. Postepy Hig Med Dosw (Online). 2013; 67:174-85. DOI: 10.5604/17322693.1038361. View

12.

Tomczyk-Socha M, Krecicka J, Misiuk-Hojlo M, Turno-Krecicka A . MicroRNA Expression in Pseudoexfoliation Syndrome with the Use of Next-Generation Sequencing. Genes (Basel). 2022; 13(4). PMC: 9031982. DOI: 10.3390/genes13040582. View

13.

Dogini D, Pascoal V, Avansini S, Vieira A, Pereira T, Lopes-Cendes I . The new world of RNAs. Genet Mol Biol. 2014; 37(1 Suppl):285-93. PMC: 3983583. DOI: 10.1590/s1415-47572014000200014. View

14.

Gartaganis S, Patsoukis N, Nikolopoulos D, Georgiou C . Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome. Eye (Lond). 2006; 21(11):1406-11. DOI: 10.1038/sj.eye.6702596. View

15.

Cho H, Seong H, Kee C, Song D, Kim S, Seo S . MicroRNA profiles in aqueous humor between pseudoexfoliation glaucoma and normal tension glaucoma patients in a Korean population. Sci Rep. 2022; 12(1):6217. PMC: 9007941. DOI: 10.1038/s41598-022-09572-4. View

16.

Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N . Serum microRNAs are promising novel biomarkers. PLoS One. 2008; 3(9):e3148. PMC: 2519789. DOI: 10.1371/journal.pone.0003148. View

17.

Koca M, Naumann G, Volkholz H . Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder?. Arch Ophthalmol. 1992; 110(12):1752-6. DOI: 10.1001/archopht.1992.01080240092038. View

18.

Beezhold K, Castranova V, Chen F . Microprocessor of microRNAs: regulation and potential for therapeutic intervention. Mol Cancer. 2010; 9:134. PMC: 2887798. DOI: 10.1186/1476-4598-9-134. View

19.

Switlik W, Szemraj J . Circulating miRNAs as non-invasive biomarkers for non-small cell lung cancer diagnosis, prognosis and prediction of treatment response. Postepy Hig Med Dosw (Online). 2017; 71(0):649-662. DOI: 10.5604/01.3001.0010.3845. View

20.

Seland J . Histopathology of the lens capsule in fibrillopathia epitheliocapsularis (FEC) or so-called senile exfoliation or pseudoexfoliation. An electron microscopic study. Acta Ophthalmol (Copenh). 1979; 57(3):477-99. DOI: 10.1111/j.1755-3768.1979.tb01832.x. View