Use It or Lose It? A Meta-Analysis on the Effects of Resistance Training Cessation (Detraining) on Muscle Size in Older Adults

This review aimed to explore the effect of resistance training cessation (detraining) on muscle size in older adults. Five databases were searched to find eligible studies. Their methodological quality was assessed using the PEDro checklist. The data were pooled in a random-effects meta-analysis. Six studies, with eight groups, were included in the review. Resistance training interventions lasted from 9 to 24 weeks. The detraining duration was from 12 to 52 weeks. Studies were classified as being of fair or good methodological quality. Compared to the baseline data, muscle size significantly increased following the resistance training intervention (Cohen's : 0.99; 95% confidence interval: 0.63, 1.36). Compared to the post-resistance training data, there was a significant decrease in muscle size following training cessation (Cohen's : -0.83; 95% confidence interval: -1.30, -0.36). In subgroup analyses, there was no significant decrease in muscle size following 12-24 weeks of training cessation (Cohen's : -0.60; 95% confidence interval: -1.21, 0.01). There was a significant decrease in muscle size following 31-52 weeks of training cessation (Cohen's : -1.11; 95% confidence interval: -1.75, -0.47). In summary, resistance training increases muscle size in older adults. In contrast, training cessation is associated with a decrease in muscle size. However, the loss of muscle size might be related to detraining duration, with greater muscle loss occurring during longer duration detraining periods. Future studies are required to establish the time course of muscle size changes during detraining in older adults.