The Versatile Role of MiR-21 in Renal Homeostasis and Diseases

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Nov 11

PMID 36359921

Authors

Romain Larrue

Sandy Fellah

Cynthia Van der Hauwaert

Marie-Flore Hennino

Michael Perrais

Arnaud Lionet

Francois Glowacki

Nicolas Pottier

Christelle Cauffiez

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21's involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.

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References

Xu X, Kriegel A, Liu Y, Usa K, Mladinov D, Liu H . Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int. 2012; 82(11):1167-75. PMC: 3777822. DOI: 10.1038/ki.2012.241. View

Kowalczyk A, Krazinski B, Godlewski J, Grzegrzolka J, Kiewisz J, Kwiatkowski P . SATB1 is Down-regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR-21-5p Overexpression and Poor Prognosis. Cancer Genomics Proteomics. 2016; 13(3):209-17. View

Androsavich J, Chau B, Bhat B, Linsley P, Walter N . Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver. RNA. 2012; 18(8):1510-26. PMC: 3404372. DOI: 10.1261/rna.033308.112. View

Laurent L . MicroRNAs in embryonic stem cells and early embryonic development. J Cell Mol Med. 2009; 12(6A):2181-8. PMC: 4514098. DOI: 10.1111/j.1582-4934.2008.00513.x. View

An F, Liu Y, Hu Y . miR-21 inhibition of LATS1 promotes proliferation and metastasis of renal cancer cells and tumor stem cell phenotype. Oncol Lett. 2017; 14(4):4684-4688. PMC: 5649614. DOI: 10.3892/ol.2017.6746. View

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M . MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008; 456(7224):980-4. DOI: 10.1038/nature07511. View

Harvey S, Jarad G, Cunningham J, Goldberg S, Schermer B, Harfe B . Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 2008; 19(11):2150-8. PMC: 2573015. DOI: 10.1681/ASN.2008020233. View

Liu L, Pang X, Shang W, Xie H, Feng Y, Feng G . Long non-coding RNA GAS5 sensitizes renal cell carcinoma to sorafenib via miR-21/SOX5 pathway. Cell Cycle. 2018; 18(3):257-263. PMC: 6380417. DOI: 10.1080/15384101.2018.1475826. View

Petrozza V, Carbone A, Bellissimo T, Porta N, Palleschi G, Pastore A . Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma. Int J Mol Sci. 2015; 16(12):29219-25. PMC: 4691105. DOI: 10.3390/ijms161226160. View

10.

Ramalingam P, Palanichamy J, Singh A, Das P, Bhagat M, Kassab M . Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA. 2013; 20(1):76-87. PMC: 3866646. DOI: 10.1261/rna.041814.113. View

11.

Agrawal P, Heimbruch K, Rao S . Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease. Compr Physiol. 2018; 9(1):439-455. PMC: 6566905. DOI: 10.1002/cphy.c180028. View

12.

Lee R, Ambros V . An extensive class of small RNAs in Caenorhabditis elegans. Science. 2001; 294(5543):862-4. DOI: 10.1126/science.1065329. View

13.

Wettersten H, Abu Aboud O, Lara Jr P, Weiss R . Metabolic reprogramming in clear cell renal cell carcinoma. Nat Rev Nephrol. 2017; 13(7):410-419. DOI: 10.1038/nrneph.2017.59. View

14.

Chen X, Li R, Li X, Peng X, Zhang C, Liu K . Identification of a four-microRNA panel in serum for screening renal cell carcinoma. Pathol Res Pract. 2021; 227:153625. DOI: 10.1016/j.prp.2021.153625. View

15.

Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal V . miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med. 2010; 207(8):1589-97. PMC: 2916139. DOI: 10.1084/jem.20100035. View

16.

Sequeira-Lopez M, Weatherford E, Borges G, Monteagudo M, Pentz E, Harfe B . The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol. 2010; 21(3):460-7. PMC: 2831866. DOI: 10.1681/ASN.2009090964. View

17.

Pavkovic M, Riefke B, Ellinger-Ziegelbauer H . Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury. Toxicology. 2014; 324:147-57. DOI: 10.1016/j.tox.2014.05.005. View

18.

Wang J, Gao Y, Zhang N, Zou D, Wang P, Zhu Z . miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol Cell Endocrinol. 2014; 392(1-2):163-72. DOI: 10.1016/j.mce.2014.05.018. View

19.

Gaudelot K, Gibier J, Pottier N, Hemon B, Van Seuningen I, Glowacki F . Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma. Tumour Biol. 2017; 39(7):1010428317707372. DOI: 10.1177/1010428317707372. View

20.

Poliseno L, Salmena L, Zhang J, Carver B, Haveman W, Pandolfi P . A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010; 465(7301):1033-8. PMC: 3206313. DOI: 10.1038/nature09144. View