Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Nov 11

PMID 36358116

Authors

Zeinab Maghsodian

Ali Mohammad Sanati

Tebogo Mashifana

Mika Sillanpaa

Shengyu Feng

Tan Nhat

Bahman Ramavandi

Affiliations

Soon will be listed here.

Abstract

Antibiotics, as pollutants of emerging concern, can enter marine environments, rivers, and lakes and endanger ecology and human health. The purpose of this study was to review the studies conducted on the presence of antibiotics in water, sediments, and organisms in aquatic environments (i.e., seas, rivers, and lakes). Most of the reviewed studies were conducted in 2018 (15%) and 2014 (11%). Antibiotics were reported in aqueous media at a concentration of <1 ng/L−100 μg/L. The results showed that the highest number of works were conducted in the Asian continent (seas: 74%, rivers: 78%, lakes: 87%, living organisms: 100%). The highest concentration of antibiotics in water and sea sediments, with a frequency of 49%, was related to fluoroquinolones. According to the results, the highest amounts of antibiotics in water and sediment were reported as 460 ng/L and 406 ng/g, respectively. In rivers, sulfonamides had the highest abundance (30%). Fluoroquinolones (with an abundance of 34%) had the highest concentration in lakes. Moreover, the highest concentration of fluoroquinolones in living organisms was reported at 68,000 ng/g, with a frequency of 39%. According to the obtained results, it can be concluded that sulfonamides and fluoroquinolones are among the most dangerous antibiotics due to their high concentrations in the environment. This review provides timely information regarding the presence of antibiotics in different aquatic environments, which can be helpful for estimating ecological risks, contamination levels, and their management.

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References

Anh H, Le T, Le N, Lu X, Duong T, Garnier J . Antibiotics in surface water of East and Southeast Asian countries: A focused review on contamination status, pollution sources, potential risks, and future perspectives. Sci Total Environ. 2020; 764:142865. DOI: 10.1016/j.scitotenv.2020.142865. View

Wu S, Hua P, Gui D, Zhang J, Ying G, Krebs P . Occurrences, transport drivers, and risk assessments of antibiotics in typical oasis surface and groundwater. Water Res. 2022; 225:119138. DOI: 10.1016/j.watres.2022.119138. View

Giedraitiene A, Vitkauskiene A, Naginiene R, Pavilonis A . Antibiotic resistance mechanisms of clinically important bacteria. Medicina (Kaunas). 2011; 47(3):137-46. View

Archundia D, Duwig C, Lehembre F, Chiron S, Morel M, Prado B . Antibiotic pollution in the Katari subcatchment of the Titicaca Lake: Major transformation products and occurrence of resistance genes. Sci Total Environ. 2016; 576:671-682. DOI: 10.1016/j.scitotenv.2016.10.129. View

Imwene K, Ngumba E, Kairigo P . Emerging technologies for enhanced removal of residual antibiotics from source-separated urine and wastewaters: A review. J Environ Manage. 2022; 322:116065. DOI: 10.1016/j.jenvman.2022.116065. View

Ding H, Wu Y, Zhang W, Zhong J, Lou Q, Yang P . Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China. Chemosphere. 2017; 184:137-147. DOI: 10.1016/j.chemosphere.2017.05.148. View

Mirzaei R, Mesdaghinia A, Hoseini S, Yunesian M . Antibiotics in urban wastewater and rivers of Tehran, Iran: Consumption, mass load, occurrence, and ecological risk. Chemosphere. 2019; 221:55-66. DOI: 10.1016/j.chemosphere.2018.12.187. View

Chen H, Liu S, Xu X, Zhou G, Liu S, Yue W . Antibiotics in the coastal environment of the Hailing Bay region, South China Sea: Spatial distribution, source analysis and ecological risks. Mar Pollut Bull. 2015; 95(1):365-73. DOI: 10.1016/j.marpolbul.2015.04.025. View

Hu Y, Yan X, Shen Y, Di M, Wang J . Antibiotics in surface water and sediments from Hanjiang River, Central China: Occurrence, behavior and risk assessment. Ecotoxicol Environ Saf. 2018; 157:150-158. DOI: 10.1016/j.ecoenv.2018.03.083. View

10.

Chen Q, Guo X, Hua G, Li G, Feng R, Liu X . Migration and degradation of swine farm tetracyclines at the river catchment scale: Can the multi-pond system mitigate pollution risk to receiving rivers?. Environ Pollut. 2016; 220(Pt B):1301-1310. DOI: 10.1016/j.envpol.2016.11.004. View

11.

Elmahdi S, DaSilva L, Parveen S . Antibiotic resistance of Vibrio parahaemolyticus and Vibrio vulnificus in various countries: A review. Food Microbiol. 2016; 57:128-34. DOI: 10.1016/j.fm.2016.02.008. View

12.

Yang Y, Cao X, Lin H, Wang J . Antibiotics and Antibiotic Resistance Genes in Sediment of Honghu Lake and East Dongting Lake, China. Microb Ecol. 2016; 72(4):791-801. DOI: 10.1007/s00248-016-0814-9. View

13.

Gao L, Shi Y, Li W, Niu H, Liu J, Cai Y . Occurrence of antibiotics in eight sewage treatment plants in Beijing, China. Chemosphere. 2011; 86(6):665-71. DOI: 10.1016/j.chemosphere.2011.11.019. View

14.

Liu X, Lu S, Meng W, Zheng B . Residues and health risk assessment of typical antibiotics in aquatic products from the Dongting Lake, China-"Did you eat "Antibiotics" today?". Environ Sci Pollut Res Int. 2017; 25(4):3913-3921. DOI: 10.1007/s11356-017-0745-0. View

15.

Fu C, Xu B, Chen H, Zhao X, Li G, Zheng Y . Occurrence and distribution of antibiotics in groundwater, surface water, and sediment in Xiong'an New Area, China, and their relationship with antibiotic resistance genes. Sci Total Environ. 2021; 807(Pt 2):151011. DOI: 10.1016/j.scitotenv.2021.151011. View

16.

Chen K, Zhou J . Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. Chemosphere. 2013; 95:604-12. DOI: 10.1016/j.chemosphere.2013.09.119. View

17.

Zhanel G, Dueck M, Hoban D, Vercaigne L, Embil J, Gin A . Review of macrolides and ketolides: focus on respiratory tract infections. Drugs. 2001; 61(4):443-98. DOI: 10.2165/00003495-200161040-00003. View

18.

Al Aukidy M, Verlicchi P, Jelic A, Petrovic M, Barcelo D . Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. Sci Total Environ. 2012; 438:15-25. DOI: 10.1016/j.scitotenv.2012.08.061. View

19.

Zhang R, Kang Y, Zhang R, Han M, Zeng W, Wang Y . Occurrence, source, and the fate of antibiotics in mariculture ponds near the Maowei Sea, South China: Storm caused the increase of antibiotics usage. Sci Total Environ. 2020; 752:141882. DOI: 10.1016/j.scitotenv.2020.141882. View

20.

Zheng Q, Zhang R, Wang Y, Pan X, Tang J, Zhang G . Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities. Mar Environ Res. 2012; 78:26-33. DOI: 10.1016/j.marenvres.2012.03.007. View