Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives

Overview

Journal Bioengineering (Basel)

Date 2022 Nov 10

PMID 36354516

Authors

Junjun Li

Li Liu

Jingbo Zhang

Xiang Qu

Takuji Kawamura

Shigeru Miyagawa

Yoshiki Sawa

Affiliations

Soon will be listed here.

Abstract

Heart failure (HF) is the leading cause of death worldwide. The most effective HF treatment is heart transplantation, the use of which is restricted by the limited supply of donor hearts. The human pluripotent stem cell (hPSC), including human embryonic stem cell (hESC) and the induced pluripotent stem cells (hiPSC), could be produced in an infinite manner and differentiated into cardiomyocytes (CMs) with high efficiency. The hPSC-CMs have, thus, offered a promising alternative for heart transplant. In this review, we introduce the tissue-engineering technologies for hPSC-CM, including the materials for cell culture and tissue formation, and the delivery means into the heart. The most recent progress in clinical application of hPSC-CMs is also introduced. In addition, the bottleneck limitations and future perspectives for clinical translation are further discussed.

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