Management of Cancer-related Fatigue in Taiwan: an Evidence-based Consensus for Screening, Assessment and Treatment

Overview

Journal Jpn J Clin Oncol

Publisher Oxford University Press

Specialty Oncology

Date 2022 Nov 10

PMID 36354095

Authors

Kun-Ming Rau

Shiow-Ching Shun

Shih-Hsin Hung

Hsiu-Ling Chou

Ching-Liang Ho

Ta-Chung Chao

Chun-Yu Liu

Ching-Ting Lien

Ming-Ying Hong

Ching-Jung Wu

Li-Yun Tsai

Sui-Whi Jane

Ruey-Kuen Hsieh

Affiliations

Soon will be listed here.

Abstract

Background: Cancer-related fatigue is one of the most common and persistent issues experienced by cancer patients. Cancer-related fatigue is a distinct form of fatigue that is subjective, long-lasting and unalleviated by rest or sleep. Studies have shown that almost all cancer patients experience severe fatigue that disrupts the quality of life and physical function, but cancer-related fatigue remains under-addressed in clinical care, and only about half of all patients receive treatment.

Methods: To increase the awareness of cancer-related fatigue and improve current management, the Taiwan Society of Cancer Palliative Medicine and the Taiwan Oncology Nursing Society convened a consensus committee to develop recommendations for the screening, assessment and treatment of cancer-related fatigue.

Results: Thirteen consensus recommendations were subsequently developed based on the best available evidence and the clinical experience of committee members.

Conclusions: These recommendations are expected to facilitate the standardization of cancer-related fatigue management across Taiwan and may also serve as a reference for other clinicians.

References

Bruera E, Yennurajalingam S, Palmer J, Perez-Cruz P, Frisbee-Hume S, Allo J . Methylphenidate and/or a nursing telephone intervention for fatigue in patients with advanced cancer: a randomized, placebo-controlled, phase II trial. J Clin Oncol. 2013; 31(19):2421-7. PMC: 3691358. DOI: 10.1200/JCO.2012.45.3696. View

Barton D, Liu H, Dakhil S, Linquist B, Sloan J, Nichols C . Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013; 105(16):1230-8. PMC: 3888141. DOI: 10.1093/jnci/djt181. View

Mustian K, Alfano C, Heckler C, Kleckner A, Kleckner I, Leach C . Comparison of Pharmaceutical, Psychological, and Exercise Treatments for Cancer-Related Fatigue: A Meta-analysis. JAMA Oncol. 2017; 3(7):961-968. PMC: 5557289. DOI: 10.1001/jamaoncol.2016.6914. View

van der Lee M, Garssen B . Mindfulness-based cognitive therapy reduces chronic cancer-related fatigue: a treatment study. Psychooncology. 2012; 21(3):264-72. DOI: 10.1002/pon.1890. View

Lai Y, Shun S, Hsiao Y, Chiou J, Wei L, Tsai J . Fatigue experiences in hepatocellular carcinoma patients during six weeks of stereotactic radiotherapy. Oncologist. 2007; 12(2):221-30. DOI: 10.1634/theoncologist.12-2-221. View

Mucke M, Mochamat , Cuhls H, Peuckmann-Post V, Minton O, Stone P . Pharmacological treatments for fatigue associated with palliative care: executive summary of a Cochrane Collaboration systematic review. J Cachexia Sarcopenia Muscle. 2016; 7(1):23-7. PMC: 4799864. DOI: 10.1002/jcsm.12101. View

Savard J, Simard S, Ivers H, Morin C . Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part II: Immunologic effects. J Clin Oncol. 2005; 23(25):6097-106. DOI: 10.1200/JCO.2005.12.513. View

Bamodu O, Kuo K, Wang C, Huang W, Wu A, Tsai J . (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. Nutrients. 2019; 11(10). PMC: 6836209. DOI: 10.3390/nu11102264. View

Greer S, Moorey S, Baruch J, Watson M, ROBERTSON B, Mason A . Adjuvant psychological therapy for patients with cancer: a prospective randomised trial. BMJ. 1992; 304(6828):675-80. PMC: 1881503. DOI: 10.1136/bmj.304.6828.675. View

10.

Berger A, Kuhn B, Farr L, Lynch J, Agrawal S, Chamberlain J . Behavioral therapy intervention trial to improve sleep quality and cancer-related fatigue. Psychooncology. 2008; 18(6):634-46. DOI: 10.1002/pon.1438. View

11.

Bower J, Ganz P, Desmond K, Rowland J, Meyerowitz B, Belin T . Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol. 2000; 18(4):743-53. DOI: 10.1200/JCO.2000.18.4.743. View

12.

Rau K, Shun S, Chiou T, Lu C, Ko W, Lee M . A nationwide survey of fatigue in cancer patients in Taiwan: an unmet need. Jpn J Clin Oncol. 2020; 50(6):693-700. PMC: 7284537. DOI: 10.1093/jjco/hyaa038. View

13.

Velthuis M, Agasi-Idenburg S, Aufdemkampe G, Wittink H . The effect of physical exercise on cancer-related fatigue during cancer treatment: a meta-analysis of randomised controlled trials. Clin Oncol (R Coll Radiol). 2010; 22(3):208-21. DOI: 10.1016/j.clon.2009.12.005. View

14.

Chen H, Lin I, Chen Y, Chang K, Wu M, Su W . A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med. 2012; 35(1):E1-11. DOI: 10.25011/cim.v35i1.16100. View

15.

Bruera E, Roca E, Cedaro L, Carraro S, Chacon R . Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep. 1985; 69(7-8):751-4. View

16.

van Haren I, Timmerman H, Potting C, Blijlevens N, Staal J, Nijhuis-van Der Sanden M . Physical exercise for patients undergoing hematopoietic stem cell transplantation: systematic review and meta-analyses of randomized controlled trials. Phys Ther. 2012; 93(4):514-28. DOI: 10.2522/ptj.20120181. View

17.

Duijts S, Faber M, Oldenburg H, van Beurden M, Aaronson N . Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors--a meta-analysis. Psychooncology. 2010; 20(2):115-26. DOI: 10.1002/pon.1728. View

18.

Alfano C, Day J, Katz M, Herndon 2nd J, Bittoni M, Oliveri J . Exercise and dietary change after diagnosis and cancer-related symptoms in long-term survivors of breast cancer: CALGB 79804. Psychooncology. 2008; 18(2):128-33. PMC: 3934632. DOI: 10.1002/pon.1378. View

19.

Bower J . Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014; 11(10):597-609. PMC: 4664449. DOI: 10.1038/nrclinonc.2014.127. View

20.

Larkin D, Lopez V, Aromataris E . Managing cancer-related fatigue in men with prostate cancer: a systematic review of non-pharmacological interventions. Int J Nurs Pract. 2013; 20(5):549-60. DOI: 10.1111/ijn.12211. View