Precisely Controlling the Cellular Internalization of DNA-decorated Semiconductor Polymer Nanoparticles for Drug Delivery

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Nov 9

PMID 36349005

Authors

Ying Tan

Mengyi Xiong

Qin Liu

Yao Yin

Xia Yin

Shiyi Liao

Youjuan Wang

Ling Hu

Xiao-Bing Zhang

Affiliations

Soon will be listed here.

Abstract

Nonspecific adhesivity of nanoparticles to cells is regarded as a significant issue of nanomedicine, which brings about many serious drawbacks in applications, including low detection sensitivity, non-targeted biotoxicity and poor diagnostic accuracy. Here, we propose for the first time, DNA-decorated semiconductor polymer nanoparticles (SPN-DNAs), whose adhesivity can be significantly alleviated by controlling the density and thickness of DNA layers. This property is demonstrated to be independent of external conditions such as temperature, concentration, incubation time, ionic strength and cell lines. The mechanism of this phenomenon is also discussed. Finally, based on minimized nonspecific adhesivity to cells, a triggered nanoswitch can be constructed to control cellular internalization and drug delivery.

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