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Development of Neuropathic Arthropathy With Entrectinib: Case Report

Overview
Journal JTO Clin Res Rep
Date 2022 Nov 7
PMID 36340796
Authors
Nicholas P Giustini
Hanna Oh
Keith D Eaton
Affiliations
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Abstract

TRK inhibition can lead to on-target neurologic adverse events. Two cases illustrate the development of neuropathic arthropathy as a side effect of entrectinib. After starting entrectinib, both patients developed foot pain, swelling, and sensory changes with magnetic resonance imaging revealing marrow edema. Providers should have a low threshold to investigate foot pain or gait abnormalities thoroughly with magnetic resonance imaging and referral to specialists to aid in the diagnosis of neuropathic arthropathy, with consideration to transition to an alternative agent.

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