One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Nov 7

PMID 36340104

Authors

Grigorii K Sterligov

Alexandra A Ageshina

Sergey A Rzhevskiy

Olga V Shurupova

Maxim A Topchiy

Lidiya I Minaeva

Andrey F Asachenko

Affiliations

Soon will be listed here.

Abstract

A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding -(-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials.

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