Extracts Induce Apoptosis and Inhibit Tumor Invasion Blockage of the PI3K/AKT Signaling in Melanoma Cells

Overview

Journal Front Pharmacol

Date 2022 Nov 7

PMID 36339598

Authors

Xin Hu

Kui Zhang

Guangzhao Pan

Yinggang Wang

Yue Shen

Cheng Peng

Longfei Deng

Hongjuan Cui

Affiliations

Soon will be listed here.

Abstract

Melanoma, the most aggressive and deadliest form of skin cancer, has attracted increased attention due to its increasing incidence worldwide. The (CM) has long been used as a classical traditional Chinese medicine (TCM) to treat various diseases, including cancer. The bioactive components and underlying mechanisms, however, remain largely unknown. The current study aims to investigate the anti-melanoma effects of CM and potential mechanisms through combined network pharmacology and bioinformatic analyses, and validated by and experiments. We report here that CM has anti-melanoma activity both and . Furthermore, 25 bioactive compounds in CM were found to share 142 melanoma targets, and network pharmacology and enrichment analyses suggested that CM inhibits melanoma through multiple biological processes and signaling pathways, particularly the PI3K-AKT signaling inhibition and activation of apoptotic pathways, which were further confirmed by biochemical and histological examinations. Finally, partial CM-derived bioactive compounds were found to show anti-melanoma effects, validating the anti-melanoma potential of bioactive ingredients of CM. Taken together, these results reveal bioactive components and mechanisms of CM in inhibiting melanoma, providing them as potential anti-cancer natural products for the treatment of melanoma.

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