L. As a Source of Anticancer Agents: Phytochemistry to Mechanistic Insight

Overview

Journal Explor Target Antitumor Ther

Specialty Oncology

Date 2022 Nov 7

PMID 36338520

Authors

Ajay Kumar

Shivani Attri

Sandeep Kaur

Hardeep Singh Tuli

Reena V Saini

Adesh Kumar Saini

Manoj Kumar

Satwinderjeet Kaur

Affiliations

Soon will be listed here.

Abstract

(.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments. The bioactive constituents present in the genus . include benzoquinones, naphthazarins, alkaloids, phenolic, naphthoquinones, and flavonoids whereas shikonins and onosmins are the most significant. The review compiled contemporary research on . L., including its distribution, morphology, traditional applications, phytochemistry, ethnopharmacology, and toxicology. This review also highlights a few critical challenges and possible future directions for . L. research. Modern research has demonstrated a wide range of pharmacological effects of different species of . L., including anti-diabetic, anticancer, anti-inflammatory, and cardiovascular protective. However, the studies on the . genus are still not fully explored, therefore, researchers need to discover novel products with their toxicity studies, molecular mechanism, and associated side effects. Future exploration of potent constituents from this genus and clinical trials are required to explore its pharmacological importance.

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References

Saravanakumar K, Sarikurkcu C, Sahinler S, Sarikurkcu R, Wang M . Phytochemical Composition, Antioxidant, and Enzyme Inhibition Activities of Methanolic Extracts of Two Endemic Species. Plants (Basel). 2021; 10(7). PMC: 8309465. DOI: 10.3390/plants10071373. View

Sagratini G, Cristalli G, Giardina D, Gioventu G, Maggi F, Ricciutelli M . Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification. J Sep Sci. 2008; 31(6-7):945-52. DOI: 10.1002/jssc.200700408. View

Mohammadi Bazargani M, Falahati-Anbaran M, Rohloff J . Comparative Analyses of Phytochemical Variation Within and Between Congeneric Species of Willow Herb, and : Contribution of Environmental Factors. Front Plant Sci. 2021; 11:595190. PMC: 7925418. DOI: 10.3389/fpls.2020.595190. View

Kundakovic T, Stanojkovic T, Juranic Z, Kovacevic N . Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria. Phytother Res. 2006; 20(7):602-4. DOI: 10.1002/ptr.1899. View

DANDIYA P, Arora R . A phytochemical and pharmacological study of Onosma bracteatum Wall. J Am Pharm Assoc Am Pharm Assoc. 1957; 46(2):111-4. DOI: 10.1002/jps.3030460210. View

Asif H, Hayee A, Aslam M, Ahmad K, Hashmi A . Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models. Dose Response. 2019; 17(4):1559325819891262. PMC: 6891010. DOI: 10.1177/1559325819891262. View

Binzet R . , a new species of Boraginaceae from Turkey. PhytoKeys. 2016; (69):39-49. PMC: 5029139. DOI: 10.3897/phytokeys.69.8360. View

Kumar A, Kaur V, Pandit K, Tuli H, Sak K, Jain S . Antioxidant Phytoconstituents From Wall. (Boraginaceae) Ameliorate the CCl Induced Hepatic Damage: Study in Male Wistar Rats. Front Pharmacol. 2020; 11:1301. PMC: 7472603. DOI: 10.3389/fphar.2020.01301. View

Kumar A, Kaur S, Pandit K, Kaur V, Thakur S, Kaur S . Onosma bracteata Wall. induces G/G arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT/GSK3β/cyclin E pathway. Environ Sci Pollut Res Int. 2020; 28(12):14983-15004. DOI: 10.1007/s11356-020-11466-9. View

10.

Roeder E, Wiedenfeld H . Pyrrolizidine alkaloids in medicinal plants of Mongolia, Nepal and Tibet. Pharmazie. 2010; 64(11):699-716. View

11.

Papageorgiou V, Assimopoulou A, Ballis A . Alkannins and shikonins: a new class of wound healing agents. Curr Med Chem. 2008; 15(30):3248-67. DOI: 10.2174/092986708786848532. View

12.

Cao L, Xue Y, Yang Z, Li Y, Li H, Chen X . Shikonofuran E plays an anti-inflammatory role by down-regulating MAPK and NF-κB signaling pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. J Nat Med. 2018; 73(1):244-251. DOI: 10.1007/s11418-018-1238-2. View

13.

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A . Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview. Medicines (Basel). 2018; 5(3). PMC: 6165118. DOI: 10.3390/medicines5030093. View

14.

Pan Y, Liu Y, Fujii R, Farooq U, Cheng L, Matsuura A . Ehretiquinone from Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction. Oxid Med Cell Longev. 2021; 2021:5469849. PMC: 7822689. DOI: 10.1155/2021/5469849. View

15.

Sut S, Pavela R, Kolarcik V, Cappellacci L, Petrelli R, Maggi F . Identification of Onosma visianii Roots Extract and Purified Shikonin Derivatives as Potential Acaricidal Agents against Tetranychus urticae. Molecules. 2017; 22(6). PMC: 6152756. DOI: 10.3390/molecules22061002. View

16.

Engel N, Ali I, Adamus A, Frank M, Dad A, Ali S . Antitumor evaluation of two selected Pakistani plant extracts on human bone and breast cancer cell lines. BMC Complement Altern Med. 2016; 16:244. PMC: 4960692. DOI: 10.1186/s12906-016-1215-9. View

17.

Nikita G, Vivek P, Chhaya G . Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides. Nat Prod Res. 2015; 29(16):1584-8. DOI: 10.1080/14786419.2014.986126. View

18.

Sharma S, Khan N, Sultana S . Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin. Life Sci. 2004; 75(20):2391-410. DOI: 10.1016/j.lfs.2004.04.030. View

19.

Pellikainen J, Ropponen K, Kataja V, Kellokoski J, Eskelinen M, Kosma V . Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clin Cancer Res. 2004; 10(22):7621-8. DOI: 10.1158/1078-0432.CCR-04-1061. View

20.

Aj Jabbar A . : Phytochemical composition, antioxidant, cytotoxicity, and acute oral toxicity. Food Sci Nutr. 2021; 9(10):5755-5764. PMC: 8498047. DOI: 10.1002/fsn3.2544. View