Unique Pathologic Features and Gene Expression Signatures Distinguish Blastoid High-grade B-cell Lymphoma from B-acute Lymphoblastic Leukemia/lymphoma

Overview

Journal Haematologica

Specialty Hematology

Date 2022 Nov 3

PMID 36325892

Authors

Lianqun Qiu

Jie Xu

Pei Lin

Evan N Cohen

Guilin Tang

Sa A Wang

Mahsa Khanlari

Wei Wang

Joseph D Khoury

Sergej Konoplev

C Cameron Yin

Jeffrey L Jorgensen

Francisco Vega

L Jeffrey Medeiros

Shaoying Li

Affiliations

Soon will be listed here.

Citing Articles

Large B-Cell Lymphomas in the 5th Edition of the WHO-Classification of Haematolymphoid Neoplasms-Updated Classification and New Concepts.

Kurz K, Ott M, Kalmbach S, Steinlein S, Kalla C, Horn H Cancers (Basel). 2023; 15(8).

PMID: 37190213 PMC: 10137297. DOI: 10.3390/cancers15082285.

Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop.

Duffield A, Dogan A, Amador C, Cook J, Czader M, Goodlad J Am J Clin Pathol. 2023; .

PMID: 37167543 PMC: 10233403. DOI: 10.1093/ajcp/aqad042.

Blastoid B-Cell Neoplasms: Diagnostic Challenges and Solutions.

Qiu L, Wang S, Tang G, Wang W, Lin P, Xu J Cancers (Basel). 2023; 15(3).

PMID: 36765805 PMC: 9913171. DOI: 10.3390/cancers15030848.

References

Ali Shah M, Ahmad U, Tariq Mahmood M, Ahmad A, Bakar M . Frequency of CD34 and CD10 Expression in Adolescent and Young Adult Patients Having Precursor B-cell Acute Lymphoblastic Leukemia and Its Correlation With Clinical Outcomes: A Single-Center Study. Cureus. 2022; 14(1):e21261. PMC: 8842122. DOI: 10.7759/cureus.21261. View

Alaggio R, Amador C, Anagnostopoulos I, Attygalle A, de Oliveira Araujo I, Berti E . The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022; 36(7):1720-1748. PMC: 9214472. DOI: 10.1038/s41375-022-01620-2. View

Uchida A, Isobe Y, Uemura Y, Nishio Y, Sakai H, Kato M . De novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with and and/or rearrangements: a case report and literature review. BMC Clin Pathol. 2017; 17:21. PMC: 5679186. DOI: 10.1186/s12907-017-0060-1. View

Bhavsar S, Liu Y, Gibson S, Moore E, Swerdlow S . Mutational Landscape of TdT+ Large B-cell Lymphomas Supports Their Distinction From B-lymphoblastic Neoplasms: A Multiparameter Study of a Rare and Aggressive Entity. Am J Surg Pathol. 2021; 46(1):71-82. DOI: 10.1097/PAS.0000000000001750. View

Campo E, Jaffe E, Cook J, Quintanilla-Martinez L, Swerdlow S, Anderson K . The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022; 140(11):1229-1253. PMC: 9479027. DOI: 10.1182/blood.2022015851. View

Garg N, Gupta R, Kotru M . CD34 is not Expressed by Blasts in a Third of B-ALL Patients and its Negativity is associated with Aberrant Marker Expression: A Retrospective Analysis. Asian Pac J Cancer Prev. 2021; 22(3):919-925. PMC: 8286681. DOI: 10.31557/APJCP.2021.22.3.919. View

Ramakrishnan Geethakumari P, Hoffmann M, Pemmaraju N, Hu S, Jorgensen J, OBrien S . Extramedullary B lymphoblastic leukemia/lymphoma (B-ALL/B-LBL): a diagnostic challenge. Clin Lymphoma Myeloma Leuk. 2014; 14(4):e115-8. PMC: 4403758. DOI: 10.1016/j.clml.2014.01.004. View

Kanagal-Shamanna R, Medeiros L, Lu G, Wang S, Manning J, Lin P . High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis. Histopathology. 2012; 61(5):945-54. DOI: 10.1111/j.1365-2559.2012.04301.x. View

Khanlari M, Medeiros L, Lin P, Xu J, You M, Tang G . Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge. Mod Pathol. 2021; 35(3):419-426. DOI: 10.1038/s41379-021-00909-4. View

10.

Ok C, Medeiros L, Thakral B, Tang G, Jain N, Jabbour E . High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma. Mod Pathol. 2018; 32(1):48-58. DOI: 10.1038/s41379-018-0112-9. View

11.

Liu W, Hu S, Konopleva M, Khoury J, Kalhor N, Tang G . De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis. Pediatr Hematol Oncol. 2015; 32(8):535-47. DOI: 10.3109/08880018.2015.1087611. View

12.

Fujimoto A, Ikejiri F, Arakawa F, Ito S, Okada Y, Takahashi F . Simultaneous Discordant B-Lymphoblastic Lymphoma and Follicular Lymphoma. Am J Clin Pathol. 2020; 155(2):308-317. DOI: 10.1093/ajcp/aqaa126. View

13.

Slot L, Hoogeboom R, Smit L, Wormhoudt T, Biemond B, Oud M . B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains. Am J Pathol. 2016; 186(12):3273-3284. DOI: 10.1016/j.ajpath.2016.07.027. View