Preeclampsia and Its Relationship to Pathological Brain Aging

Overview

Journal Front Physiol

Date 2022 Nov 3

PMID 36324311

Authors

Abigail A Testo

Carole McBride

Ira M Bernstein

Julie A Dumas

Affiliations

Soon will be listed here.

Abstract

The development of preeclampsia during pregnancy may have long-term effects on brain aging in women. Associations between preeclampsia and vascular dementia have been established, however the connection between preeclampsia and Alzheimer's disease has not been as thoroughly explored. Both preeclampsia and Alzheimer's disease have been associated with misfolded amyloid beta proteins and inflammation; due to these similarities, in this minireview, we examined the potential links between a history of preeclampsia and the development of dementia. We also discussed how hypertensive disorders of pregnancy may relate to both normal brain aging and dementia to highlight the need for additional research regarding the long-term cognitive effects of preeclampsia on the brain.

Citing Articles

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.

Amabebe E, Huang Z, Jash S, Krishnan B, Cheng S, Nakashima A Biomedicines. 2025; 13(1).

PMID: 39857613 PMC: 11763151. DOI: 10.3390/biomedicines13010029.

Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.

Miller E, Conley P, Alirezaei M, Wolfova K, Gonzales M, Tan Z Lancet Healthy Longev. 2024; 5(12):100660.

PMID: 39675366 PMC: 11726346. DOI: 10.1016/j.lanhl.2024.100660.

Subclinical Metabolic and Cardiovascular Factors and Brain White Matter Microstructural Integrity in Young Women.

McBride C, Russom Z, Bernstein I, Dumas J Reprod Sci. 2024; 31(7):1895-1902.

PMID: 38565839 DOI: 10.1007/s43032-024-01516-9.

Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia.

Medegan Fagla B, Buhimschi I Molecules. 2024; 29(3).

PMID: 38338354 PMC: 10856193. DOI: 10.3390/molecules29030610.

Dementia: a looming threat for women with hypertensive disorders of pregnancy?.

Abe M, Arima H Hypertens Res. 2024; 47(4):975-977.

PMID: 38337006 DOI: 10.1038/s41440-024-01588-9.

References

Minciullo P, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G . Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. Arch Immunol Ther Exp (Warsz). 2015; 64(2):111-26. DOI: 10.1007/s00005-015-0377-3. View

Friis T, Wikstrom A, Acurio J, Leon J, Zetterberg H, Blennow K . Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia. Cells. 2022; 11(5). PMC: 8909006. DOI: 10.3390/cells11050789. View

Fields J, Garovic V, Mielke M, Kantarci K, Jayachandran M, White W . Preeclampsia and cognitive impairment later in life. Am J Obstet Gynecol. 2017; 217(1):74.e1-74.e11. PMC: 5615406. DOI: 10.1016/j.ajog.2017.03.008. View

Au A, Feher A, McPhee L, Jessa A, Oh S, Einstein G . Estrogens, inflammation and cognition. Front Neuroendocrinol. 2016; 40:87-100. DOI: 10.1016/j.yfrne.2016.01.002. View

Osol G, Bernstein I . Preeclampsia and maternal cardiovascular disease: consequence or predisposition?. J Vasc Res. 2014; 51(4):290-304. DOI: 10.1159/000367627. View

Zambrano M, Miller E . Maternal Stroke: an Update. Curr Atheroscler Rep. 2019; 21(9):33. PMC: 6815220. DOI: 10.1007/s11883-019-0798-2. View

Andolf E, Sydsjo G, Bladh M, Berg G, Sharma S . Hypertensive disorders in pregnancy and later dementia: a Swedish National Register Study. Acta Obstet Gynecol Scand. 2017; 96(4):464-471. DOI: 10.1111/aogs.13096. View

Elharram M, Dayan N, Kaur A, Landry T, Pilote L . Long-Term Cognitive Impairment After Preeclampsia: A Systematic Review and Meta-analysis. Obstet Gynecol. 2018; 132(2):355-364. DOI: 10.1097/AOG.0000000000002686. View

van Abel D, Michel O, Veerhuis R, Jacobs M, van Dijk M, Oudejans C . Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease. J Alzheimers Dis. 2012; 31(4):793-800. DOI: 10.3233/JAD-2012-120472. View

10.

Newcombe E, Camats-Perna J, Silva M, Valmas N, Jong Huat T, Medeiros R . Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation. 2018; 15(1):276. PMC: 6154824. DOI: 10.1186/s12974-018-1313-3. View

11.

Andersson M, Oras J, Thorn S, Karlsson O, Kalebo P, Zetterberg H . Signs of neuroaxonal injury in preeclampsia-A case control study. PLoS One. 2021; 16(2):e0246786. PMC: 7869986. DOI: 10.1371/journal.pone.0246786. View

12.

Rosano C, Marsland A, Gianaros P . Maintaining brain health by monitoring inflammatory processes: a mechanism to promote successful aging. Aging Dis. 2012; 3(1):16-33. PMC: 3320802. View

13.

Freed K, Cooper D, Brennecke S, Moses E . Detection of CAG repeats in pre-eclampsia/eclampsia using the repeat expansion detection method. Mol Hum Reprod. 2005; 11(7):481-7. DOI: 10.1093/molehr/gah190. View

14.

Siepmann T, Boardman H, Bilderbeck A, Griffanti L, Kenworthy Y, Zwager C . Long-term cerebral white and gray matter changes after preeclampsia. Neurology. 2017; 88(13):1256-1264. PMC: 5373775. DOI: 10.1212/WNL.0000000000003765. View

15.

Nelander M, Cnattingius S, Akerud H, Wikstrom J, Pedersen N, Wikstrom A . Pregnancy hypertensive disease and risk of dementia and cardiovascular disease in women aged 65 years or older: a cohort study. BMJ Open. 2016; 6(1):e009880. PMC: 4735184. DOI: 10.1136/bmjopen-2015-009880. View

16.

Bergman L, Hastie R, Zetterberg H, Blennow K, Schell S, Langenegger E . Evidence of Neuroinflammation and Blood-Brain Barrier Disruption in Women with Preeclampsia and Eclampsia. Cells. 2021; 10(11). PMC: 8616341. DOI: 10.3390/cells10113045. View

17.

Tariq S, Barber P . Dementia risk and prevention by targeting modifiable vascular risk factors. J Neurochem. 2017; 144(5):565-581. DOI: 10.1111/jnc.14132. View

18.

Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M . Preeclampsia and eclampsia: the conceptual evolution of a syndrome. Am J Obstet Gynecol. 2022; 226(2S):S786-S803. PMC: 8941666. DOI: 10.1016/j.ajog.2021.12.001. View

19.

Cater J, Manucat-Tan N, Georgiou D, Zhao G, Buhimschi I, Wyatt A . A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone. Cells. 2022; 11(7). PMC: 8997907. DOI: 10.3390/cells11071152. View

20.

Ciampa E, Li Y, Dillon S, Lecarpentier E, Sorabella L, Libermann T . Cerebrospinal Fluid Protein Changes in Preeclampsia. Hypertension. 2018; 72(1):219-226. DOI: 10.1161/HYPERTENSIONAHA.118.11153. View