Pregnancies Complicated by Gestational Diabetes and Fetal Growth Restriction: an Analysis of Maternal and Fetal Body Composition Using Magnetic Resonance Imaging

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2022 Nov 2

PMID 36319757

Authors

Katie M Strobel

Sevgi Gokce Kafali

Shu-Fu Shih

Alexandra M Artura

Rinat Masamed

David Elashoff

Holden H Wu

Kara L Calkins

Affiliations

Soon will be listed here.

Abstract

Introduction: Maternal body composition may influence fetal body composition.

Objective: The objective of this pilot study was to investigate the relationship between maternal and fetal body composition.

Methods: Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation.

Results: Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2 [4.2, 5.5]% vs. 3.2 [3, 3.3]% vs. 1.9 [1.4, 3.7]%, p = 0.004). Fetal hepatic PDFF was associated with maternal SAT (r = 0.47, p = 0.02), VAT (r = 0.62, p = 0.002), and pancreatic PDFF (r = 0.54, p = 0.008). When controlling for maternal SAT, GDM increased fetal hepatic PDFF by 0.9 ([0.51, 1.3], p = 0.001).

Conclusion: In this study, maternal SAT, VAT, and GDM status were positively associated with fetal hepatic PDFF.

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