A Concise Pathophysiological Model of Acute Appendicitis Against the Background of the COVID-19 Pandemic

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2022 Oct 31

PMID 36313868

Authors

Marc Reismann

Affiliations

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Abstract

One of the most common clinical pictures has become the focus of attention during the COVID-19 pandemic: acute appendicitis with the associated diagnostics and therapy. The aim of the work is to show inconsistencies with regard to epidemiology, pathophysiology and therapy against the background of the pandemic with special attention to the conditions for children and to explain the pathophysiological processes that are likely to underlie the disease based on scientifically plausible models.

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References

Rosenthal M, Fakhry S, Morse J, Wyse R, Garland J, Duane T . Where Did All the Appendicitis Go? Impact of the COVID-19 Pandemic on Volume, Management, and Outcomes of Acute Appendicitis in a Nationwide, Multicenter Analysis. Ann Surg Open. 2023; 2(1):e048. PMC: 10455274. DOI: 10.1097/AS9.0000000000000048. View

Chavasse R . Covid-19: reduced asthma presentations in children. BMJ. 2020; 370:m2806. DOI: 10.1136/bmj.m2806. View

Hiraiwa H, Umemoto M, Take H . Prevalence of appendectomy in Japanese families. Acta Paediatr Jpn. 1995; 37(6):691-3. DOI: 10.1111/j.1442-200x.1995.tb03405.x. View

Ruber M, Andersson M, Petersson B, Olaison G, Andersson R, Ekerfelt C . Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis. Surgery. 2009; 147(3):366-72. DOI: 10.1016/j.surg.2009.09.039. View

Kuroda K, Stottlemyre M . Acute Appendicitis Associated With Kawasaki Disease: Case Report and Review of the Literature. Cureus. 2021; 13(10):e18997. PMC: 8608400. DOI: 10.7759/cureus.18997. View

Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y . Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 2007; 178(7):4466-72. DOI: 10.4049/jimmunol.178.7.4466. View

Livingston E, Woodward W, Sarosi G, Haley R . Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007; 245(6):886-92. PMC: 1876946. DOI: 10.1097/01.sla.0000256391.05233.aa. View

Neufeld M, Bauerle W, Eriksson E, Azar F, Evans H, Johnson M . Where did the patients go? Changes in acute appendicitis presentation and severity of illness during the coronavirus disease 2019 pandemic: A retrospective cohort study. Surgery. 2020; 169(4):808-815. PMC: 7717883. DOI: 10.1016/j.surg.2020.10.035. View

Richardsen I, Schob D, Ulmer T, Steinau G, Neumann U, Klink C . Etiology of Appendicitis in Children: The Role of Bacterial and Viral Pathogens. J Invest Surg. 2015; 29(2):74-9. DOI: 10.3109/08941939.2015.1065300. View

10.

Laurin M, Everett M, Parker W . The cecal appendix: one more immune component with a function disturbed by post-industrial culture. Anat Rec (Hoboken). 2011; 294(4):567-79. DOI: 10.1002/ar.21357. View

11.

Ceresoli M, Coccolini F, Magnone S, Lucianetti A, Bisagni P, Armao T . The decrease of non-complicated acute appendicitis and the negative appendectomy rate during pandemic. Eur J Trauma Emerg Surg. 2021; 47(5):1359-1365. PMC: 8040760. DOI: 10.1007/s00068-021-01663-7. View

12.

Andreou P, Blain S, du Boulay C . A histopathological study of the appendix at autopsy and after surgical resection. Histopathology. 1990; 17(5):427-31. DOI: 10.1111/j.1365-2559.1990.tb00763.x. View

13.

Andersson R, Hugander A, Thulin A, Nystrom P, Olaison G . Indications for operation in suspected appendicitis and incidence of perforation. BMJ. 1994; 308(6921):107-10. PMC: 2539237. DOI: 10.1136/bmj.308.6921.107. View

14.

Larner A . The aetiology of appendicitis. Br J Hosp Med. 1988; 39(6):540-2. View

15.

Miyauchi H, Okata Y, Hatakeyama T, Nakatani T, Nakai Y, Bitoh Y . Analysis of predictive factors for perforated appendicitis in children. Pediatr Int. 2020; 62(6):711-715. DOI: 10.1111/ped.14148. View

16.

Arlt A, Bharti R, Ilves I, Hasler R, Miettinen P, Paajanen H . Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis. Innate Immun. 2013; 21(1):30-41. DOI: 10.1177/1753425913515033. View

17.

Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A . Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020; 15(1):27. PMC: 7386163. DOI: 10.1186/s13017-020-00306-3. View

18.

Burgard M, Cherbanyk F, Nassiopoulos K, Malekzadeh S, Pugin F, Egger B . An effect of the COVID-19 pandemic: Significantly more complicated appendicitis due to delayed presentation of patients!. PLoS One. 2021; 16(5):e0249171. PMC: 8148360. DOI: 10.1371/journal.pone.0249171. View

19.

Bollinger R, Barbas A, Bush E, Lin S, Parker W . Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. J Theor Biol. 2007; 249(4):826-31. DOI: 10.1016/j.jtbi.2007.08.032. View

20.

Rawolle T, Reismann M, Minderjahn M, Bassir C, Hauptmann K, Rothe K . Sonographic differentiation of complicated from uncomplicated appendicitis. Br J Radiol. 2019; 92(1099):20190102. PMC: 6636276. DOI: 10.1259/bjr.20190102. View