Insulin-like Peptide 3 in Domestic Animals with Normal and Abnormal Reproductive Functions, in Comparison to Rodents and Humans

Overview

Journal Reprod Med Biol

Specialty Biology

Date 2022 Oct 31

PMID 36310659

Authors

Noritoshi Kawate

Affiliations

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Abstract

Background: Insulin-like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However, little to no review articles focusing on INSL3 in domestic animals exist.

Methods: The author reviewed the past and recent literature regarding the structure, expression, roles of INSL3 in the reproductive organs, and its circulation under normal and aberrant reproductive conditions in domestic animals in comparison with rodents and humans.

Main Findings: As with humans and rodents, blood INSL3 concentrations rise around puberty in normal male domestic animals and are associated with testicular size. INSL3 levels are acutely upregulated by luteinizing hormone (LH), and the increase is smaller than that of testosterone in male ruminants, whereas the acute regulation of INSL3 by LH does not occur in human men. Dogs with cryptorchidism and bulls with abnormal semen have lowered INSL3 levels.

Conclusion: The findings regarding INSL3 secretions in male domestic animals with normal and aberrant reproductive functions illustrate similar or dissimilar points to humans and rodents. Data on blood INSL3 levels in normal and abnormal female domestic species are still limited and require further investigation.

Citing Articles

Spermatic RXFP2 expression levels and seminal INSL3 concentrations among beef bull ejaculates with different levels of sperm morphological normality.

Wimalarathne H, Arashi K, Iwaki F, Sakase M, Duritahala , Harayama H J Reprod Dev. 2024; 71(1):35-40.

PMID: 39721672 PMC: 11808304. DOI: 10.1262/jrd.2024-072.

Insulin-like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans.

Kawate N Reprod Med Biol. 2022; 21(1):e12485.

PMID: 36310659 PMC: 9601793. DOI: 10.1002/rmb2.12485.

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