Blood Flow Restriction Accelerates Aerobic Training-induced Adaptation of [Formula: See Text] Kinetics at the Onset of Moderate-intensity Exercise

Overview

Journal Sci Rep

Specialty Science

Date 2022 Oct 28

PMID 36307460

Authors

Amane Hori

Ryuji Saito

Kenichi Suijo

Michael R Kushnick

Daisuke Hasegawa

Koji Ishida

Norio Hotta

Affiliations

Soon will be listed here.

Abstract

It is unclear whether blood flow restriction (BFR) accelerates the adaptation of the time constant (τ) of phase II oxygen uptake ([Formula: see text]) kinetics in the moderate-intensity exercise domain via moderate-intensity aerobic training. Therefore, healthy participants underwent moderate-intensity [45-60% [Formula: see text] Reserve] aerobic cycle training with or without BFR (BFR group, n = 9; CON group, n = 9) for 8 weeks to evaluate [Formula: see text] kinetics during moderate-intensity cycle exercise before (Pre) and after 4 (Mid) and 8 (Post) weeks of training. Both groups trained for 30 min, 3 days weekly. BFR was performed for 5 min every 10 min by applying cuffs to the upper thighs. The τ significantly decreased by Mid in the BFR group (23.7 ± 2.9 s [Pre], 15.3 ± 1.8 s [Mid], 15.5 ± 1.4 s [Post], P < 0.01) and by Post in the CON group (27.5 ± 2.0 s [Pre], 22.1 ± 0.7 s [Mid], 18.5 ± 1.9 s [Post], P < 0.01). Notably, the BFR group's τ was significantly lower than that of the CON group at Mid (P < 0.01) but not at Post. In conclusion, BFR accelerates the adaptation of the [Formula: see text] kinetics of phase II by moderate-intensity aerobic training.

References

Carter H, Jones A, Barstow T, Burnley M, Williams C, Doust J . Effect of endurance training on oxygen uptake kinetics during treadmill running. J Appl Physiol (1985). 2000; 89(5):1744-52. DOI: 10.1152/jappl.2000.89.5.1744. View

Shirai K, Saiki A, Nagayama D, Tatsuno I, Shimizu K, Takahashi M . The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases. Pulse (Basel). 2015; 3(2):118-33. PMC: 4646158. DOI: 10.1159/000431235. View

Loenneke J, Wilson J, Wilson G, Pujol T, Bemben M . Potential safety issues with blood flow restriction training. Scand J Med Sci Sports. 2011; 21(4):510-8. DOI: 10.1111/j.1600-0838.2010.01290.x. View

Sprick J, Rickards C . Combining remote ischemic preconditioning and aerobic exercise: a novel adaptation of blood flow restriction exercise. Am J Physiol Regul Integr Comp Physiol. 2017; 313(5):R497-R506. PMC: 5792145. DOI: 10.1152/ajpregu.00111.2017. View

Convertino V, Goldwater D, Sandler H . VO2 kinetics of constant-load exercise following bed-rest-induced deconditioning. J Appl Physiol Respir Environ Exerc Physiol. 1984; 57(5):1545-50. DOI: 10.1152/jappl.1984.57.5.1545. View

Whipp B, Ward S, Lamarra N, Davis J, Wasserman K . Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol Respir Environ Exerc Physiol. 1982; 52(6):1506-13. DOI: 10.1152/jappl.1982.52.6.1506. View

Hotta N, Yamamoto K, Sato K, Katayama K, Fukuoka Y, Ishida K . Ventilatory and circulatory responses at the onset of dominant and non-dominant limb exercise. Eur J Appl Physiol. 2007; 101(3):347-58. DOI: 10.1007/s00421-007-0500-1. View

Horiuchi M, Okita K . Blood flow restricted exercise and vascular function. Int J Vasc Med. 2012; 2012:543218. PMC: 3485988. DOI: 10.1155/2012/543218. View

Krustrup P, Jones A, Wilkerson D, Calbet J, Bangsbo J . Muscular and pulmonary O2 uptake kinetics during moderate- and high-intensity sub-maximal knee-extensor exercise in humans. J Physiol. 2009; 587(Pt 8):1843-56. PMC: 2683969. DOI: 10.1113/jphysiol.2008.166397. View

10.

Poole D, Barstow T, McDonough P, Jones A . Control of oxygen uptake during exercise. Med Sci Sports Exerc. 2008; 40(3):462-74. DOI: 10.1249/MSS.0b013e31815ef29b. View

11.

Ozaki H, Loenneke J, Abe T . Blood flow-restricted walking in older women: does the acute hormonal response associate with muscle hypertrophy?. Clin Physiol Funct Imaging. 2015; 37(4):379-383. DOI: 10.1111/cpf.12312. View

12.

Renzi C, Tanaka H, Sugawara J . Effects of leg blood flow restriction during walking on cardiovascular function. Med Sci Sports Exerc. 2009; 42(4):726-32. PMC: 2888901. DOI: 10.1249/MSS.0b013e3181bdb454. View

13.

Poole D, Jones A . Oxygen uptake kinetics. Compr Physiol. 2013; 2(2):933-96. DOI: 10.1002/cphy.c100072. View

14.

Burgomaster K, Moore D, Schofield L, Phillips S, Sale D, Gibala M . Resistance training with vascular occlusion: metabolic adaptations in human muscle. Med Sci Sports Exerc. 2003; 35(7):1203-8. DOI: 10.1249/01.MSS.0000074458.71025.71. View

15.

Grassi B, Poole D, Richardson R, Knight D, Erickson B, Wagner P . Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol (1985). 1996; 80(3):988-98. DOI: 10.1152/jappl.1996.80.3.988. View

16.

Ferguson R, Hunt J, Lewis M, Martin N, Player D, Stangier C . The acute angiogenic signalling response to low-load resistance exercise with blood flow restriction. Eur J Sport Sci. 2018; 18(3):397-406. DOI: 10.1080/17461391.2017.1422281. View

17.

Barstow T, Buchthal S, Zanconato S, Cooper D . Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J Appl Physiol (1985). 1994; 77(4):1742-9. DOI: 10.1152/jappl.1994.77.4.1742. View

18.

Korzeniewski B, Rossiter H, Zoladz J . Mechanisms underlying extremely fast muscle V˙O on-kinetics in humans. Physiol Rep. 2018; 6(16):e13808. PMC: 6113137. DOI: 10.14814/phy2.13808. View

19.

Abe T, Sakamaki M, Fujita S, Ozaki H, Sugaya M, Sato Y . Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults. J Geriatr Phys Ther. 2010; 33(1):34-40. View

20.

Chilibeck P, Paterson D, McCreary C, Marsh G, Cunningham D, Thompson R . The effects of age on kinetics of oxygen uptake and phosphocreatine in humans during exercise. Exp Physiol. 1998; 83(1):107-17. DOI: 10.1113/expphysiol.1998.sp004087. View