The Conundrum of Diabetic Neuropathies-Past, Present, and Future

Overview

Journal J Diabetes Complications

Specialty Endocrinology

Date 2022 Oct 28

PMID 36306721

Authors

Lynn Ang

Kara Mizokami-Stout

Stephanie A Eid

Melissa Elafros

Brian Callaghan

Eva L Feldman

Rodica Pop-Busui

Affiliations

Soon will be listed here.

Abstract

Diabetic neuropathy (DN) remains arguably the most prevalent chronic complication in people with both type 1 and type 2 diabetes, including in youth, despite changes in the current standards of clinical care. Additionally, emerging evidence demonstrates that neuropathy affects a large proportion of people with undiagnosed diabetes and/or prediabetes, as well as those with obesity. Here we summarize the latest epidemiology of DN, recent findings regarding the pathophysiology of the disease, as well as current outcome measures for screening and diagnosis, in research and clinical settings. The authors discuss novel perspectives on the impact of social determinants of health in DN development and management, and the latest evidence on effective therapies, including pharmacological and nonpharmacological therapies for neuropathic pain. Throughout the publication, we identify knowledge gaps and the need for future funding to address these gaps, as well as needs to advocate for a personalized care approach to reduce the burden of DN and optimize quality of life for all affected individuals.

Citing Articles

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Assessing Chronic Pain Among Adults Diagnosed with Diabetes Residing in Rural Appalachia.

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