Recent Advances in the Use of Dimethyl Sulfoxide As a Synthon in Organic Chemistry

Overview

Journal Top Curr Chem (Cham)

Publisher Springer

Specialty Chemistry

Date 2022 Oct 28

PMID 36306032

Authors

Hao Lu

Zhou Tong

Lifen Peng

Zhiqing Wang

Shuang-Feng Yin

Nobuaki Kambe

Renhua Qiu

Affiliations

Soon will be listed here.

Abstract

Dimethyl sulfoxide (DMSO), as extremely important aprotic polar solvent and reaction medium, has attracted widespread attention from chemists in recent years due to its wide range of uses and the multiple functions it displays in various chemical processes. Especially in the past decade, dimethyl sulfoxide has become increasingly favored as a synthon in organic chemistry, resulting in great progress in this research field. In this context, this review provides a comprehensive summary of the literature on the recent progress in organic synthesis using dimethyl sulfoxide as a synthon, covering all the reports from 1 January 2016 to 11 May 2022. This type of reaction is mainly performed by transferring one or more units of dimethyl sulfoxide, such as oxygen (-O-, =O), methyl (-CH), methylene (-CH-), methylidene (=CH), methine (=CH-), donor of formylation (-CHO), sulfur (-S-), methylthio (-SMe), methyl sulfoxide (-SOMe), donor of methyl thiomethylation (-CHSMe), or donor of methyl sulfoxide methylation (-CHSOMe), to the target molecules. At the same time, we hope that this review will stimulate future studies and promote developments in this area.

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