Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Overview

Journal J Clin Transl Hepatol

Specialty Gastroenterology

Date 2022 Oct 28

PMID 36304511

Authors

Hozeifa Mohamed Hassan

Jun Li

Affiliations

Soon will be listed here.

Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

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