Effect of AMPK Subunit Alpha 2 Polymorphisms on Postherpetic Pain Susceptibility in Southwestern Han Chinese

Overview

Journal J Pain Res

Publisher Dove Medical Press

Date 2022 Oct 28

PMID 36304487

Authors

Yang Mei

Yang Mu

Win Wang

Bo-Tao Tan

Yao-Hua Chen

Yu-Ping Li

Dan Zhu

Wei Li

Jian Cui

Le-Hua Yu

Affiliations

Soon will be listed here.

Abstract

Introduction: Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of , the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between and postherpetic neuralgia (PHN) in the southwestern Chinese Han population.

Methods: This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed.

Results: The PHN patients were older than the healthy subjects ( < 0.05); however, the other clinical characteristics between two groups were not significantly different (all >0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism ( < 0.05), but not in rs2796498 ( > 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis ( < 0.05).

Conclusion: PHN occurrence may be related to the rs10789038 A>G genetic polymorphism in the southwestern Chinese Han population.

Citing Articles

Genetic polymorphisms of and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study.

Mei Y, Chen Q, Li Y, Chen Y, Xia J, Zeng J Front Mol Neurosci. 2023; 16:1128429.

PMID: 36818655 PMC: 9928852. DOI: 10.3389/fnmol.2023.1128429.

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