Metabolic Regulation of Lysine Acetylation: Implications in Cancer

Overview

Journal Subcell Biochem

Publisher Springer

Specialty Biochemistry

Date 2022 Oct 27

PMID 36301501

Authors

Siddharth Singh

Parijat Senapati

Tapas K Kundu

Affiliations

Soon will be listed here.

Abstract

Lysine acetylation is the second most well-studied post-translational modification after phosphorylation. While phosphorylation regulates signaling cascades, one of the most significant roles of acetylation is regulation of chromatin structure. Acetyl-coenzyme A (acetyl-CoA) serves as the acetyl group donor for acetylation reactions mediated by lysine acetyltransferases (KATs). On the other hand, NAD+ serves as the cofactor for lysine deacetylases (KDACs). Both acetyl-CoA and NAD+ are metabolites integral to energy metabolism, and therefore, their metabolic flux can regulate the activity of KATs and KDACs impacting the epigenome. In this chapter, we review our current understanding of how metabolic pathways regulate lysine acetylation in normal and cancer cells.

Citing Articles

Mechanisms of metabolism-coupled protein modifications.

Zhang B, Schroeder F Nat Chem Biol. 2025; .

PMID: 39775169 DOI: 10.1038/s41589-024-01805-z.

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