Adherence to Sars-CoV2 Vaccination in Hematological Patients

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Oct 27

PMID 36300128

Authors

Justine Narinx

Margaux Houbiers

Laurence Seidel

Yves Beguin

Affiliations

Soon will be listed here.

Abstract

Background: SARS-CoV2 vaccination efficiently prevents severe COVID-19, although hematological patients, particularly under therapy, respond less well. Besides vaccine efficacy, adherence to vaccination is essential for ensuring adequate protection of this vulnerable population.

Methods: We evaluated the impact of a program aimed at maximizing patient adherence by comparing the rate of SARS-CoV2 vaccination of our hematological patients and a matched sample of the general population.

Results: Vaccination rates were 88.9% among 2,156 patients, aged 65.2 ± 15.8 years (M ± SD, range 19-86 years). Rates differed considerably with age, i.e. 84.2% between 18-64 years and 92.4% above 65 years (p<0.0001), but not with sex. In the general population, rates were 76.3% overall, 73.0% between 18-64 and 86.7% above 65 years, all significantly lower than among patients, overall (Standardized Incidence ratio (SIR) 1.17; 95%CI 1.12-1.22, p<0.0001) as well as among younger (SIR 1.15; 1.07-1.24, p<0.0001) or older (SIR 1.06; 1.00-1.13, p=0.046) people. Vaccination rates increased to 92.2% overall (SIR 1.21; 1.16-1.27, p<0.0001), 88.5% in younger (SIR 1.21; 1.13-1.30, p<0.0001) and 94.8% in older (SIR 1.09; 1.03-1.12, p=0.0043) patients, after excluding those with medical contraindications, and further to 95.6% overall (SIR 1.26; 1.20-1.32, p<0.0001), 93.8% in younger (SIR 1.29; 1.20-1.38, p<0.0001) and 96.9% in older (SIR 1.11; 1.05-1.18, p=0.0004) patients, after excluding those not seen in hematology in 2021.

Conclusions: Vaccination rates were significantly higher in hematological patients compared to the general population regardless of age, sex and municipality. Acceptance of Covid vaccines by hematological patients may be improved by targeted information campaigns carried out by trusted health care professionals.

Citing Articles

Attitudes towards COVID-19 Vaccination in Adults with Haematological Malignancies.

Blennerhassett R, Hamad N, Grech L, Kwok A, Choi T, Forsyth C Acta Haematol. 2024; 147(5):543-554.

PMID: 38290477 PMC: 11441379. DOI: 10.1159/000536548.

References

Overheu O, Lendowski S, Quast D, Marheinecke C, Kourti E, Lugnier C . Attitude towards and perception of individual safety after SARS-CoV-2 vaccination among German cancer patients. J Cancer Res Clin Oncol. 2022; 149(5):1985-1992. PMC: 9215322. DOI: 10.1007/s00432-022-04099-7. View

Souan L, Sughayer M, Abu Alhowr M, Ammar K, Bader S . An update on the impact of SARS-CoV-2 pandemic public awareness on cancer patients' COVID-19 vaccine compliance: Outcomes and recommendations. Front Public Health. 2022; 10:923815. PMC: 9354075. DOI: 10.3389/fpubh.2022.923815. View

Matovina Brko G, Popovic M, Jovic M, Radic J, Bodlovic Kladar M, Nikolic I . COVID-19 vaccines and cancer patients: acceptance, attitudes and safety. J BUON. 2021; 26(5):2183-2190. View

Jan H, Waheeb A, Alahwal H, Almohammadi A, Al-Marzouki A, Barefah A . COVID-19 Vaccine Perception and Hesitancy Among Patients With Sickle Cell Disease in the Western Region of Saudi Arabia. Cureus. 2022; 14(1):e21026. PMC: 8820497. DOI: 10.7759/cureus.21026. View

Tsai R, Hervey J, Hoffman K, Wood J, Johnson J, Deighton D . COVID-19 Vaccine Hesitancy and Acceptance Among Individuals With Cancer, Autoimmune Diseases, or Other Serious Comorbid Conditions: Cross-sectional, Internet-Based Survey. JMIR Public Health Surveill. 2021; 8(1):e29872. PMC: 8734610. DOI: 10.2196/29872. View

Day D, Grech L, Nguyen M, Bain N, Kwok A, Harris S . Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia. Vaccines (Basel). 2022; 10(6). PMC: 9230066. DOI: 10.3390/vaccines10060851. View

Moujaess E, Bou Zeid N, Samaha R, Sawan J, Kourie H, Labaki C . Perceptions of the COVID-19 vaccine among patients with cancer: a single-institution survey. Future Oncol. 2021; 17(31):4071-4079. PMC: 8328088. DOI: 10.2217/fon-2021-0265. View

Peng X, Gao P, Wang Q, Wu H, Yan Y, Xia Y . Prevalence and Impact Factors of COVID-19 Vaccination Hesitancy Among Breast Cancer Survivors: A Multicenter Cross-Sectional Study in China. Front Med (Lausanne). 2021; 8:741204. PMC: 8595240. DOI: 10.3389/fmed.2021.741204. View

Skeens M, Guttoo P, Stanek J, Taylor K, Stratz E, Ardura M . An Exploration of COVID-19 Impact and Vaccine Hesitancy in Parents of Pediatric Hematopoietic Stem Cell Transplant (HCT) Recipients. Bone Marrow Transplant. 2022; 57(4):547-553. PMC: 8785691. DOI: 10.1038/s41409-022-01587-9. View

10.

Vijenthira A, Gong I, Fox T, Booth S, Cook G, Fattizzo B . Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood. 2020; 136(25):2881-2892. PMC: 7746126. DOI: 10.1182/blood.2020008824. View

11.

Hong J, Xu X, Yang J, Zheng J, Dai S, Zhou J . Knowledge about, attitude and acceptance towards, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern China: A cross-sectional survey. J Integr Med. 2021; 20(1):34-44. PMC: 8559872. DOI: 10.1016/j.joim.2021.10.004. View

12.

Stoekle H, Sekkate S, Angellier E, Herve C, Beuzeboc P . Refusal of anti-coronavirus disease 2019 vaccination in cancer patients: Is there a difference between the sexes?. Eur J Cancer. 2021; 155:54-55. PMC: 8292033. DOI: 10.1016/j.ejca.2021.06.048. View

13.

Chun J, Kim S, Park E, Park S, Koh S, Cha Y . Cancer Patients' Willingness to Take COVID-19 Vaccination: A Nationwide Multicenter Survey in Korea. Cancers (Basel). 2021; 13(15). PMC: 8345425. DOI: 10.3390/cancers13153883. View

14.

Nguyen M, Bain N, Grech L, Choi T, Harris S, Chau H . COVID-19 vaccination rates, intent, and hesitancy in patients with solid organ and blood cancers: A multicenter study. Asia Pac J Clin Oncol. 2022; 18(6):570-577. DOI: 10.1111/ajco.13754. View

15.

Pires C . Global Predictors of COVID-19 Vaccine Hesitancy: A Systematic Review. Vaccines (Basel). 2022; 10(8). PMC: 9415631. DOI: 10.3390/vaccines10081349. View

16.

Barriere J, Gal J, Hoch B, Cassuto O, Leysalle A, Chamorey E . Acceptance of SARS-CoV-2 vaccination among French patients with cancer: a cross-sectional survey. Ann Oncol. 2021; 32(5):673-674. PMC: 7846886. DOI: 10.1016/j.annonc.2021.01.066. View

17.

Corey L, Beyrer C, Cohen M, Michael N, Bedford T, Rolland M . SARS-CoV-2 Variants in Patients with Immunosuppression. N Engl J Med. 2021; 385(6):562-566. PMC: 8494465. DOI: 10.1056/NEJMsb2104756. View

18.

Marijanovic I, Kraljevic M, Buhovac T, Sokolovic E . Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology Clinic of University Clinical Hospital Mostar, Bosnia and Herzegovina: A Cross-Sectional Study. Med Sci Monit. 2021; 27:e932788. PMC: 8596742. DOI: 10.12659/MSM.932788. View

19.

Kelkar A, Blake J, Cherabuddi K, Cornett H, McKee B, Cogle C . Vaccine Enthusiasm and Hesitancy in Cancer Patients and the Impact of a Webinar. Healthcare (Basel). 2021; 9(3). PMC: 8003419. DOI: 10.3390/healthcare9030351. View

20.

Di Noia V, Renna D, Barberi V, Di Civita M, Riva F, Costantini G . The first report on coronavirus disease 2019 (COVID-19) vaccine refusal by patients with solid cancer in Italy: Early data from a single-institute survey. Eur J Cancer. 2021; 153:260-264. PMC: 8149194. DOI: 10.1016/j.ejca.2021.05.006. View