Medicinal Plants and Natural Compounds Against Acyclovir-resistant HSV Infections

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 Oct 27

PMID 36299732

Authors

Lin Xu

Xuan-Lei Zhong

Zhi-Chao Xi

Yang Li

Hong-Xi Xu

Affiliations

Soon will be listed here.

Abstract

Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.

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