Resting-state EEG-based Convolutional Neural Network for the Diagnosis of Depression and Its Severity

The study aimed to assess the value of the resting-state electroencephalogram (EEG)-based convolutional neural network (CNN) method for the diagnosis of depression and its severity in order to better serve depressed patients and at-risk populations. In this study, we used the resting state EEG-based CNN to identify depression and evaluated its severity. The EEG data were collected from depressed patients and healthy people using the Nihon Kohden EEG-1200 system. Analytical processing of resting-state EEG data was performed using Python and MATLAB software applications. The questionnaire included the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Symptom Check-List-90 (SCL-90), and the Eysenck Personality Questionnaire (EPQ). A total of 82 subjects were included in this study, with 41 in the depression group and 41 in the healthy control group. The area under the curve (AUC) of the resting-state EEG-based CNN in depression diagnosis was 0.74 (95%CI: 0.70-0.77) with an accuracy of 66.40%. In the depression group, the SDS, SAS, SCL-90 subscales, and N scores were significantly higher in the major depression group than those in the non-major depression group ( < 0.05). The AUC of the model in depression severity was 0.70 (95%CI: 0.65-0.75) with an accuracy of 66.93%. Correlation analysis revealed that major depression AI scores were significantly correlated with SAS scores (r = 0.508, = 0.003) and SDS scores (r = 0.765, < 0.001). Our model can accurately identify the depression-specific EEG signal in terms of depression diagnosis and severity identification. It would eventually provide new strategies for early diagnosis of depression and its severity.