Vaginal Nanoformulations for the Management of Preterm Birth

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Oct 27

PMID 36297454

Authors

Asad Mir

Richa V Vartak

Ketan Patel

Steven M Yellon

Sandra E Reznik

Affiliations

Soon will be listed here.

Abstract

Preterm birth (PTB) is a leading cause of infant morbidity and mortality in the world. In 2020, 1 in 10 infants were born prematurely in the United States. The World Health Organization estimates that a total of 15 million infants are born prematurely every year. Current therapeutic interventions for PTB have had limited replicable success. Recent advancements in the field of nanomedicine have made it possible to utilize the vaginal administration route to effectively and locally deliver drugs to the female reproductive tract. Additionally, studies using murine models have provided important insights about the cervix as a gatekeeper for pregnancy and parturition. With these recent developments, the field of reproductive biology is on the cusp of a paradigm shift in the context of treating PTB. The present review focuses on the complexities associated with treating the condition and novel therapeutics that have produced promising results in preclinical studies.

Citing Articles

N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses.

Reznik S, Kashou A, Ward D, Yellon S Sci Rep. 2025; 15(1):8234.

PMID: 40065144 PMC: 11893883. DOI: 10.1038/s41598-025-93282-0.

Improving the Safety of -Dimethylacetamide (DMA) as a Potential Treatment for Preterm Birth in a Pregnant Mouse Model Using a Vaginal Nanoformulation.

Mir A, Acosta T, Concheiro-Guisan M, Yellon S, Patel K, Reznik S bioRxiv. 2025; .

PMID: 39896642 PMC: 11785104. DOI: 10.1101/2025.01.16.633348.

N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses.

Reznik S, Kashou A, Ward D, Yellon S bioRxiv. 2025; .

PMID: 39896567 PMC: 11785055. DOI: 10.1101/2025.01.16.633350.

The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders.

van Staden D, Gerber M, Lemmer H Pharmaceutics. 2024; 16(11).

PMID: 39598598 PMC: 11597179. DOI: 10.3390/pharmaceutics16111475.

Nanomedicine for Maternal and Fetal Health.

Carter D, Better M, Abbasi S, Zulfiqar F, Shapiro R, Ensign L Small. 2023; 20(41):e2303682.

PMID: 37817368 PMC: 11004090. DOI: 10.1002/smll.202303682.

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