Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2022 Oct 27

PMID 36297370

Authors

Thalita Vieira Nascimento Ximenes

Raquel Carvalho

Iluska Senna Bonfa

Vanessa Samudio Santos

Luciane Candeloro

Flavio Macedo Alves

Denise Brentan Silva

Carlos Alexandre Carollo

Karine de Cassia Freitas Gielow

Saulo Euclides Silva-Filho

Monica Cristina Toffoli-Kadri

Affiliations

Soon will be listed here.

Abstract

The aim of this study is to evaluate the efficacy of infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (HO), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with prevented the mentioned conditions, except for the production of hydrogen peroxide. prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.

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