Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives As Potent Inhibitors of α-Glucosidase and Urease

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Oct 27

PMID 36296720

Authors

Shoaib Khan

Shahid Iqbal

Mazloom Shah

Wajid Rehman

Rafaqat Hussain

Liaqat Rasheed

Hamad Alrbyawi

Ayed A Dera

Mohammed Issa Alahmdi

Rami Adel Pashameah

Eman AlZahrani

Abd-ElAziem Farouk

Affiliations

Soon will be listed here.

Abstract

A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, H-NMR, C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and α-glucosidase were evaluated against each derivative (-). When compared to their respective standard drug such as acarbose and thiourea, almost all compounds were shown to have excellent activity. Among the screened series, analogs (IC = 3.20 ± 0.40 and 2.10 ± 0.10 µM) and (IC = 2.50 ± 0.40 and 5.30 ± 0.20 µM), emerged as potent molecules when compared to the standard drugs acarbose (IC = 8.24 ± 0.08 µM) and urease (IC = 7.80 ± 0.30). Moreover, an anti-microbial study also demonstrated that analogs and were found with minimum inhibitory concentrations (MICs) in the presence of standard drugs streptomycin and terinafine.

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