Single Cell in a Gravity Field

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Oct 27

PMID 36295035

Authors

Irina V Ogneva

Affiliations

Soon will be listed here.

Abstract

The exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; however, the mechanism of reception of the altered gravity and transduction of this signal, leading to the formation of an adaptive pattern of the cell, is still poorly understood. At the same time, most of the negative changes that occur in early embryos when the force of gravity changes almost disappear by the time the new organism is born. This review is devoted to the responses of early embryos and stem cells, as well as terminally differentiated germ cells, to changes in gravity. An attempt was made to generalize the data presented in the literature and propose a possible unified mechanism for the reception by a single cell of an increase and decrease in gravity based on various deformations of the cortical cytoskeleton.

Citing Articles

The Motility of Mouse Spermatozoa Changes Differentially After 30-Minute Exposure Under Simulating Weightlessness and Hypergravity.

Ogneva I, Zhdankina Y, Gogichaeva K, Malkov A, Biryukov N Int J Mol Sci. 2025; 25(24.

PMID: 39769324 PMC: 11678010. DOI: 10.3390/ijms252413561.

Administration of Essential Phospholipids Prevents Oocytes from Responding to Change in Gravity.

Gogichaeva K, Ogneva I Cells. 2024; 13(18.

PMID: 39329774 PMC: 11430006. DOI: 10.3390/cells13181593.

Morphological Changes of 3T3 Cells under Simulated Microgravity.

Tran M, Ho C, Hoang S, Doan C, Nguyen M, Van H Cells. 2024; 13(4.

PMID: 38391957 PMC: 10887114. DOI: 10.3390/cells13040344.

The Mechanoreception in Oocyte under Modeling Micro- and Hypergravity.

Ogneva I Cells. 2023; 12(14).

PMID: 37508484 PMC: 10377865. DOI: 10.3390/cells12141819.

Oocytes after Space Flight: The Early Period of Adaptation to the Force of Gravity.

Ogneva I, Golubkova M, Biryukov N, Kotov O Cells. 2022; 11(23).

PMID: 36497128 PMC: 9736949. DOI: 10.3390/cells11233871.

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